Activation of the cannabinoid receptor by Delta super(9)-tetrahydrocannabinol reduces gamma -aminobutyric acid uptake in the globus pallidus
The interaction between GABA ( gamma -aminobutyric acid) and cannabinoids in the globus pallidus was investigated by evaluating the effects of Delta super(9)-tetrahydrocannabinol on [ super(3)H]GABA uptake into slices of rat globus pallidus. Delta super(9)-Tetrahydrocannabinol caused a concentration...
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| Veröffentlicht in: | European journal of pharmacology 1996-07, Vol.308 (2), p.161-164 |
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| container_title | European journal of pharmacology |
| container_volume | 308 |
| creator | Maneuf, Y P Nash, JE Crossman, A R Brotchie, J M |
| description | The interaction between GABA ( gamma -aminobutyric acid) and cannabinoids in the globus pallidus was investigated by evaluating the effects of Delta super(9)-tetrahydrocannabinol on [ super(3)H]GABA uptake into slices of rat globus pallidus. Delta super(9)-Tetrahydrocannabinol caused a concentration-dependent decrease in GABA uptake (51% decrease at 100 mu M Delta super(9)-tetrahydrocannabinol, IC sub(50) = 18.95 mu M). This effect was reversed in a concentration-dependent manner (IC sub(50) = 11.9 mu M) by the cannabinoid receptor antagonist SR 141716A (N-(piperidin-1-yl-)5-(4-chlorophenyl) 1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole 3-arboxiamidehydrochloride. SR 141716A alone did not affect GABA uptake. These results show that cannabinoid receptor activation reduces GABA uptake in the globus pallidus. |
| format | Article |
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Delta super(9)-Tetrahydrocannabinol caused a concentration-dependent decrease in GABA uptake (51% decrease at 100 mu M Delta super(9)-tetrahydrocannabinol, IC sub(50) = 18.95 mu M). This effect was reversed in a concentration-dependent manner (IC sub(50) = 11.9 mu M) by the cannabinoid receptor antagonist SR 141716A (N-(piperidin-1-yl-)5-(4-chlorophenyl) 1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole 3-arboxiamidehydrochloride. SR 141716A alone did not affect GABA uptake. These results show that cannabinoid receptor activation reduces GABA uptake in the globus pallidus.</abstract></addata></record> |
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| ispartof | European journal of pharmacology, 1996-07, Vol.308 (2), p.161-164 |
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| language | eng |
| recordid | cdi_proquest_miscellaneous_15830007 |
| source | Elsevier ScienceDirect Journals Complete |
| title | Activation of the cannabinoid receptor by Delta super(9)-tetrahydrocannabinol reduces gamma -aminobutyric acid uptake in the globus pallidus |
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