Abnormal Phosphorylation of Tau and the Mechanism of Alzheimer Neurofibrillary Degeneration: Sequestration of Microtubule-Associated Proteins 1 and 2 and the Disassembly of Microtubules by the Abnormal Tau

The microtubule-associated protein (MAP) tau is abnormally hyperphosphorylated in Alzheimer disease and accumulates in neurons undergoing neurofibrillary degeneration. In the present study, the associations of the Alzheimer-hyperphosphorylated tau (AD P-tau) with the high molecular weight MAPs (HMW-...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1997-01, Vol.94 (1), p.298-303
Hauptverfasser:	Alejandra Del C. Alonso, Grundke-Iqbal, Inge, Barra, Héctor S., Iqbal, Khalid
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer Disease - etiology Alzheimer Disease - metabolism Alzheimer Disease - pathology Alzheimer's disease Alzheimers disease Antibodies Binding, Competitive Biological Sciences Biology Cytosol Electron microscopy Humans Medical research Microtubule associated proteins Microtubule-Associated Proteins - metabolism Microtubule-Associated Proteins - ultrastructure Microtubules Microtubules - metabolism Microtubules - ultrastructure Neurofibrillary tangles Neurons Phosphorylation Protein Binding Proteins tau Proteins - metabolism tau Proteins - ultrastructure
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