A phase I/II study of trichosanthin treatment of HIV disease

Trichosanthin, a ribosomal inhibitor protein, blocks HIV replication in lymphocytes and macrophages. This agent was used to treat 51 patients with advanced HIV disease in a dose-escalation study in which three injections were administered over a 9-21-day period in a dose range of 10-30 micrograms/kg...

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Veröffentlicht in:	AIDS (London) 1990-12, Vol.4 (12), p.1189-1196
Hauptverfasser:	Byers, V S, Levin, A S, Waites, L A, Starrett, B A, Mayer, R A, Clegg, J A, Price, M R, Robins, R A, Delaney, M, Baldwin, R W
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Animals Antibodies - blood Body Weight Dementia - chemically induced Dose-Response Relationship, Drug Drug Evaluation Gene Products, gag - blood HIV Antigens - blood HIV Core Protein p24 HIV Infections - drug therapy HIV Infections - immunology Humans Male Mice T-Lymphocyte Subsets Trichosanthin - administration & dosage Trichosanthin - adverse effects Trichosanthin - immunology Trichosanthin - therapeutic use Viral Core Proteins - blood
Online-Zugang:	Volltext
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