l‐(−)‐Desmethylselegiline, a Metabolite of Selegiline [l‐(−)‐Deprenyl], Protects Mesencephalic Dopamine Neurons from Excitotoxicity In Vitro

: Selegiline [l‐(−)‐deprenyl], a monoamine oxidase B inhibitor, has been used in the treatment of Parkinson's disease as a putative neuroprotective agent. Selegiline is metabolized rapidly in the gastrointestinal tract and liver to desmethylselegiline (DMS) and methamphetamine. We have previous...

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Veröffentlicht in:	Journal of neurochemistry 1997-01, Vol.68 (1), p.434-436
Hauptverfasser:	Mytilineou, Catherine, Radcliffe, Pheona M., Olanow, C. Warren
Format:	Artikel
Sprache:	eng
Schlagworte:	Amphetamines - metabolism Amphetamines - pharmacology Animals Biological and medical sciences Cell Survival - drug effects Cells, Cultured Desmethylselegiline Dopamine - physiology Excitotoxicity l‐Deprenyl Medical sciences Mesencephalon - cytology Mesencephalon - drug effects Mesencephalon - physiology Monoamine Oxidase Inhibitors - pharmacology Neurons - drug effects Neurons - physiology Neuropharmacology Neuroprotection Neuroprotective agent Neuroprotective Agents - pharmacology Neurotoxins - pharmacology Parkinson's disease Pharmacology. Drug treatments Rats - embryology Selegiline
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