Dose rate and mode of exposure are key factors in JNK activation by UV irradiation

Single exposure of cells to UVC (254 nm for 30 s) or to UVB (300 nm for 10 min) was shown to activate jun-NH2 kinases which, in turn, phosphorylate their substrates ELK-1, c-jun and ATF-2. While UVC (40–80 J/m2) activates JNK up to 4 h, with maximal induction after 30 min, UVB (150–300 J/m2) activat...

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