Molecular Basis of the Catalytic Differences among DT-diaphorase of Human, Rat, and Mouse

DT-diaphorase (EC 1.6.99.2), also referred to as NAD(P)H:(quinone-acceptor) oxidoreductase, is involved in the reductive activation process of several cytotoxic antitumor quinones and nitrobenzenes. It has been observed in our and other laboratories that the rat enzyme is significantly more effectiv...

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Veröffentlicht in:	The Journal of biological chemistry 1997-01, Vol.272 (3), p.1437-1439
Hauptverfasser:	Chen, Shiuan, Knox, Richard, Wu, Kebin, Deng, Paulis S.-K., Zhou, Dujin, Bianchet, Mario A., Amzel, L. Mario
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Catalysis Humans Liver - enzymology Mice Molecular Sequence Data Mutagenesis, Site-Directed NAD(P)H Dehydrogenase (Quinone) - genetics NAD(P)H Dehydrogenase (Quinone) - metabolism Polymerase Chain Reaction Rats Sequence Homology, Amino Acid Species Specificity
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