Specific binding of the DNA repair enzyme AlkA to a pyrrolidine-based inhibitor

In the cell, DNA is continuously subjected to damage resulting from spontaneous hydrolysis, oxidation, deamination, alkylation, and errors in replication. To counter the toxic and mutagenic lesions thus produced, DNA repair enzymes are expressed in all known organisms. Whereas DNA repair was formerl...

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Veröffentlicht in:	Journal of the American Chemical Society 1995-06, Vol.117 (24), p.6623-6624
Hauptverfasser:	Schaerer, Orlando D, Ortholand, Jean-Yves, Ganesan, A, Ezaz-Nikpay, Khosro, Verdine, Gregory L
Format:	Artikel
Sprache:	eng
Schlagworte:	Escherichia coli
Online-Zugang:	Volltext
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