PREVENTION BY CYCLOHEXIMIDE OF THE AUDIOGENIC SEIZURES AND TRYPTOPHAN METABOLIC DISTURBANCES OF ETHANOL WITHDRAWAL IN RATS
Cycloheximide (20 mg/kg body wt, given intraperitoneally at —1 and 3 h after withdrawal of an ethanol-containing liquid diet) prevents the activation of liver tryptophan pyrrolase, the consequent inhibition of synthesis of brain 5-hydroxytryptamine, and the audiogenic seizures observed at 7 h after...
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| Veröffentlicht in: | Alcohol and alcoholism (Oxford) 1996-05, Vol.31 (3), p.243-247 |
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| container_end_page | 247 |
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| container_issue | 3 |
| container_start_page | 243 |
| container_title | Alcohol and alcoholism (Oxford) |
| container_volume | 31 |
| creator | ORETTI, ROSSANA BANO, SAMINA MORGAN, CHRISTOPHER J. BADAWY, ABDULLA A.-B. BONNER, ADRIAN BUCKLAND, PAUL McGUFFIN, PETER |
| description | Cycloheximide (20 mg/kg body wt, given intraperitoneally at —1 and 3 h after withdrawal of an ethanol-containing liquid diet) prevents the activation of liver tryptophan pyrrolase, the consequent inhibition of synthesis of brain 5-hydroxytryptamine, and the audiogenic seizures observed at 7 h after alcohol withdrawal. We suggest that a rapidly-turning-over protein mediates the alcohol withdrawal syndrome and discuss the possible role of liver tryptophan pyrrolase. |
| doi_str_mv | 10.1093/oxfordjournals.alcalc.a008143 |
| format | Article |
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We suggest that a rapidly-turning-over protein mediates the alcohol withdrawal syndrome and discuss the possible role of liver tryptophan pyrrolase.</description><subject>Acoustic Stimulation</subject><subject>Alcohol Withdrawal Delirium - physiopathology</subject><subject>Alcohol Withdrawal Delirium - prevention & control</subject><subject>Alcoholism and acute alcohol poisoning</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Cycloheximide - pharmacology</subject><subject>Injections, Intraperitoneal</subject><subject>Liver - drug effects</subject><subject>Liver - enzymology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Protein Synthesis Inhibitors - pharmacology</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Seizures - physiopathology</subject><subject>Seizures - prevention & control</subject><subject>Serotonin - metabolism</subject><subject>Toxicology</subject><subject>Tryptophan - metabolism</subject><subject>Tryptophan Oxygenase - antagonists & inhibitors</subject><subject>Tryptophan Oxygenase - physiology</subject><issn>0735-0414</issn><issn>1464-3502</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkEGL2zAUhEVp2abb_oSCDu3enEqWHMuHHhxbawu8dnCUZrMXITsyZJvEWyuBbX99VWIChSfeYb4Z8QaArxhNMYrIt_6164ftc38ejnpvp3rfuplqhBim5A2YYDqjHgmQ_xZMUEgCD1FM34MP1j4j5BAf34AbxihFfjQBfxY1_8FLKaoSzjcw2SRFlfNH8SBSDqt7KHMO41UqqoyXIoFLLp5WNV_CuEyhrDcLWS3yuIQPXMbzqnBEKpZyVc_jMnGUC-DS6VUB10LmaR2v4wKKEtaxXH4E7zp3gfk07luwuucyyb2iykQSF15LQ3LyZm1jOmZao3WzjXDoR1q3Omwo04xFpA3DiLjnmwYxtu38YIYCdzIOIqy32mByC-4uuS9D_-ts7EkddrY1-70-mv5sFQ4YDiglDvx-Aduht3YwnXoZdgc9_FYYqX_dq_-7V5fu1di9838ePzo3B7O9useynf5l1LV1xm7Qx3ZnrxhxGYwgh3kXbGdP5vUq6-GnmoUkDFT--KTKrFxnPssUI38BXx-aXg</recordid><startdate>19960501</startdate><enddate>19960501</enddate><creator>ORETTI, ROSSANA</creator><creator>BANO, SAMINA</creator><creator>MORGAN, CHRISTOPHER J.</creator><creator>BADAWY, ABDULLA A.-B.</creator><creator>BONNER, ADRIAN</creator><creator>BUCKLAND, PAUL</creator><creator>McGUFFIN, PETER</creator><general>Oxford University Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope></search><sort><creationdate>19960501</creationdate><title>PREVENTION BY CYCLOHEXIMIDE OF THE AUDIOGENIC SEIZURES AND TRYPTOPHAN METABOLIC DISTURBANCES OF ETHANOL WITHDRAWAL IN RATS</title><author>ORETTI, ROSSANA ; BANO, SAMINA ; MORGAN, CHRISTOPHER J. ; BADAWY, ABDULLA A.-B. ; BONNER, ADRIAN ; BUCKLAND, PAUL ; McGUFFIN, PETER</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c473t-6cbef8eceaabd91729aaca7b48a8893c77937792eb088df256050411591adae13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Acoustic Stimulation</topic><topic>Alcohol Withdrawal Delirium - physiopathology</topic><topic>Alcohol Withdrawal Delirium - prevention & control</topic><topic>Alcoholism and acute alcohol poisoning</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Cycloheximide - pharmacology</topic><topic>Injections, Intraperitoneal</topic><topic>Liver - drug effects</topic><topic>Liver - enzymology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Protein Synthesis Inhibitors - pharmacology</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Seizures - physiopathology</topic><topic>Seizures - prevention & control</topic><topic>Serotonin - metabolism</topic><topic>Toxicology</topic><topic>Tryptophan - metabolism</topic><topic>Tryptophan Oxygenase - antagonists & inhibitors</topic><topic>Tryptophan Oxygenase - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>ORETTI, ROSSANA</creatorcontrib><creatorcontrib>BANO, SAMINA</creatorcontrib><creatorcontrib>MORGAN, CHRISTOPHER J.</creatorcontrib><creatorcontrib>BADAWY, ABDULLA A.-B.</creatorcontrib><creatorcontrib>BONNER, ADRIAN</creatorcontrib><creatorcontrib>BUCKLAND, PAUL</creatorcontrib><creatorcontrib>McGUFFIN, PETER</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><jtitle>Alcohol and alcoholism (Oxford)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>ORETTI, ROSSANA</au><au>BANO, SAMINA</au><au>MORGAN, CHRISTOPHER J.</au><au>BADAWY, ABDULLA A.-B.</au><au>BONNER, ADRIAN</au><au>BUCKLAND, PAUL</au><au>McGUFFIN, PETER</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>PREVENTION BY CYCLOHEXIMIDE OF THE AUDIOGENIC SEIZURES AND TRYPTOPHAN METABOLIC DISTURBANCES OF ETHANOL WITHDRAWAL IN RATS</atitle><jtitle>Alcohol and alcoholism (Oxford)</jtitle><addtitle>Alcohol Alcohol</addtitle><date>1996-05-01</date><risdate>1996</risdate><volume>31</volume><issue>3</issue><spage>243</spage><epage>247</epage><pages>243-247</pages><issn>0735-0414</issn><eissn>1464-3502</eissn><abstract>Cycloheximide (20 mg/kg body wt, given intraperitoneally at —1 and 3 h after withdrawal of an ethanol-containing liquid diet) prevents the activation of liver tryptophan pyrrolase, the consequent inhibition of synthesis of brain 5-hydroxytryptamine, and the audiogenic seizures observed at 7 h after alcohol withdrawal. We suggest that a rapidly-turning-over protein mediates the alcohol withdrawal syndrome and discuss the possible role of liver tryptophan pyrrolase.</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><pmid>8844029</pmid><doi>10.1093/oxfordjournals.alcalc.a008143</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Alcohol and alcoholism (Oxford), 1996-05, Vol.31 (3), p.243-247 |
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| language | eng |
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| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current); EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Acoustic Stimulation Alcohol Withdrawal Delirium - physiopathology Alcohol Withdrawal Delirium - prevention & control Alcoholism and acute alcohol poisoning Animals Biological and medical sciences Cycloheximide - pharmacology Injections, Intraperitoneal Liver - drug effects Liver - enzymology Male Medical sciences Protein Synthesis Inhibitors - pharmacology Rats Rats, Wistar Seizures - physiopathology Seizures - prevention & control Serotonin - metabolism Toxicology Tryptophan - metabolism Tryptophan Oxygenase - antagonists & inhibitors Tryptophan Oxygenase - physiology |
| title | PREVENTION BY CYCLOHEXIMIDE OF THE AUDIOGENIC SEIZURES AND TRYPTOPHAN METABOLIC DISTURBANCES OF ETHANOL WITHDRAWAL IN RATS |
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