Inhibition of TC-1 cytokine production, effector cytotoxic T lymphocyte development and alloantibody production by 2,3,7,8-tetrachlorodibenzo-p- dioxin

2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD), a widespread environmental contaminant and prototypic ligand for the aryl hydrocarbon receptor, is a potent immunotoxicant. To understand the underlying mechanisms of TCDD immunotoxicity, we have characterized the time course of changes in CTL, alloantibod...

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Veröffentlicht in:	The Journal of immunology (1950) 1996-09, Vol.157 (6), p.2310-2319
Hauptverfasser:	Kerkvliet, NI, Baecher-Steppan, L, Shepherd, DM, Oughton, JA, Vorderstrasse, BA, DeKrey, GK
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibody-Dependent Cell Cytotoxicity - drug effects Antilymphocyte Serum - biosynthesis CD4-Positive T-Lymphocytes - drug effects CD8-Positive T-Lymphocytes - classification CD8-Positive T-Lymphocytes - drug effects Cytokines - antagonists & inhibitors Cytokines - biosynthesis Cytotoxicity Tests, Immunologic Female Immunoglobulin Isotypes - drug effects Immunoglobulin Isotypes - immunology Immunophenotyping Immunosuppressive Agents - toxicity Interferon-gamma - biosynthesis Interferon-gamma - drug effects Interferon-gamma - genetics Interleukin-2 - biosynthesis Interleukin-2 - genetics Isoantibodies - biosynthesis Isoantibodies - drug effects Lymphocyte Activation - drug effects Lymphocyte Count - drug effects Lymphocyte Depletion Male Mast-Cell Sarcoma Mice Mice, Inbred C57BL Mice, Inbred DBA Neoplasm Transplantation Polychlorinated Dibenzodioxins - toxicity RNA, Messenger - drug effects Spleen - cytology T-Lymphocytes, Cytotoxic - drug effects T-Lymphocytes, Cytotoxic - immunology Tumor Cells, Cultured Tumor Necrosis Factor-alpha - drug effects Tumor Necrosis Factor-alpha - genetics
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