Vancomycin does not enhance amikacin-induced tubular nephrotoxicity in children

A three-drug antibiotic regimen including vancomycin and amikacin has been recommended as effective treatment in clinical settings in which Gram-positive bacteremias are a serious problem. To determine if vancomycin potentiates the tubular proteinuria associated with amikacin therapy, we studied feb...

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Veröffentlicht in:	The Pediatric infectious disease journal 1989-05, Vol.8 (5), p.278-282
Hauptverfasser:	GOREN, M. P, BAKER, D. K. JR, SHENEP, J. L
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Amikacin - adverse effects Animals Biological and medical sciences Child Child, Preschool Clinical Trials as Topic Double-Blind Method Drug Synergism Drug Therapy, Combination Drug toxicity and drugs side effects treatment Female Fever - complications Humans Kidney Diseases - chemically induced Kidney Diseases - drug therapy Kidney Tubules - drug effects Male Medical sciences Neutropenia - complications Pharmacology. Drug treatments Proteinuria - chemically induced Random Allocation Rats Ticarcillin - administration & dosage Toxicity: urogenital system Vancomycin - pharmacology Vancomycin - toxicity
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