Production of a recombinant human monoclonal antibody using a novel hollow fiber bioreactor system

The amplified ras oncogene was used to enhance the productivity of BHK-21 cells producing a lung cancer-reactive human recombinant AE6F4 monoclonal antibody. The recombinant antibody (18 mg) was produced by the ras-amplified BHK-21 cells in a one-month high-density culture using the novel hollow fib...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of fermentation and bioengineering 1996, Vol.81 (5), p.466-469
Hauptverfasser:	Inoue, Yuichi, Kawamoto, Seiji, Seki, Kiyohiko, Teruya, Kiichiro, Mochizuki, Katsumi, Kato, Masatoshi, Hashizume, Shuichi, Yasumoto, Kosei, Nagashima, Akira, Nakahashi, Hisashi, Suzuki, Tatsuo, Imai, Tadaaki, Nomoto, Kikuo, Shirahata, Sanetaka
Format:	Artikel
Sprache:	eng
Schlagworte:	BHK-21 cells Biological and medical sciences Biotechnology Fundamental and applied biological sciences. Psychology Health. Pharmaceutical industry high density culture hollow fiber bioreactor Industrial applications and implications. Economical aspects Monoclonal antibodies Production of active biomolecules ras oncogene recombinant human monoclonal antibody
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	The amplified ras oncogene was used to enhance the productivity of BHK-21 cells producing a lung cancer-reactive human recombinant AE6F4 monoclonal antibody. The recombinant antibody (18 mg) was produced by the ras-amplified BHK-21 cells in a one-month high-density culture using the novel hollow fiber bioreactor system Tecnomouse.
ISSN:	0922-338X
DOI:	10.1016/0922-338X(96)85150-6