Selective action of 3'-azido-3'-deoxythymidine 5'-triphosphate on viral reverse transcriptases and human DNA polymerases

The action of 3'-azido-3'-deoxythymidine 5'-triphosphate (N3dTTP) on DNA strand elongation catalyzed by human immunodeficiency virus type 1 reverse transcriptase was evaluated in comparison with human DNA polymerase alpha and proliferating cell nuclear antigen-independent DNA polymera...

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Veröffentlicht in:	The Journal of biological chemistry 1990-07, Vol.265 (20), p.11914-11918
Hauptverfasser:	PENG HUANG, FARQUHAR, D, PLUNKETT, W
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibiotics. Antiinfectious agents. Antiparasitic agents Antiviral agents Antiviral Agents - pharmacology Avian Myeloblastosis Virus - enzymology Base Sequence Biological and medical sciences Cell Line Dideoxynucleotides DNA Polymerase II - antagonists & inhibitors DNA Polymerase II - isolation & purification DNA Polymerase III DNA-Directed DNA Polymerase - isolation & purification HIV - enzymology human immunodeficiency virus 1 Humans Medical sciences Molecular Sequence Data Moloney murine leukemia virus - enzymology Nucleic Acid Synthesis Inhibitors Oligonucleotide Probes Pharmacology. Drug treatments Reverse Transcriptase Inhibitors Substrate Specificity Thymine Nucleotides - metabolism Thymine Nucleotides - pharmacology Zidovudine - analogs & derivatives Zidovudine - metabolism Zidovudine - pharmacology
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