Genetic toxicology of lead compounds

We have investigated the activity of insoluble and soluble lead compounds in inducing mutagenesis, cell transformation and sister chromatid exchange in mammalian cells. Insoluble lead sulfide, readily phagocytized, was more than four times as toxic to V79 cells on a μM basis, than two moderately sol...

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Veröffentlicht in:	Carcinogenesis (New York) 1988-10, Vol.9 (10), p.1727-1732
Hauptverfasser:	Zelikoff, J. T., Li, J. H., Hartwig, A., Wang, X.W., Costa, M., Rossman, T. G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Carcinogens Cell Line Cell Transformation, Neoplastic Chemical mutagenesis Hypoxanthine Phosphoribosyltransferase - genetics Hypoxanthine Phosphoribosyltransferase - metabolism Lead - pharmacology Lead - toxicity Medical sciences Methylnitronitrosoguanidine - toxicity Mutagenicity Tests - methods Mutagens Phagocytosis - drug effects Sister Chromatid Exchange - drug effects Toxicology
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