Specific alterations in the biological activities of C-20'-modified vinblastine congeners

Both the anti-tumor and toxic activities of the vinca alkaloid dimers, vinblastine (VBL) and vincristine (VCR), may reside at the level of their known cellular target, the microtubule system. The contributions made by each of the various actions of these alkaloids on this system are unknown. We have...

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Veröffentlicht in:	Biochemical pharmacology 1989-03, Vol.38 (5), p.715-724
Hauptverfasser:	Borman, Linda S., Kuehne, Martin E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic agents Biological and medical sciences Cattle Cells, Cultured Dose-Response Relationship, Drug General aspects Medical sciences Microtubules - drug effects Mitosis - drug effects Nephelometry and Turbidimetry Pharmacology. Drug treatments Structure-Activity Relationship Tubulin - metabolism Vinblastine - analogs & derivatives Vinblastine - pharmacology
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