Altered Na super(+)-channel function as an in vitro model of the ischemic penumbra: Action of lubeluzole and other neuroprotective drugs

Veratridine blocks Na+-channel inactivation and causes a persistant Na+-influx. Exposure of hippocampal slices to 10 mu M veratridine led to a failure of synaptic transmission, repetitive spreading depression (SD)-like depolarizations of increasing duration, loss of Ca+-homeostasis, a large reductio...

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Veröffentlicht in:	Brain research 1997-01, Vol.745 (1-2), p.210-221
Hauptverfasser:	Ashton, D, Willems, R, Wynants, J, Van Reempts, J, Marrannes, R, Clincke, G
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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