Etretinate embrytoxicity 7 months after discontinuation of treatment

Etretinate embrytoxicity 7 months after discontinuation of treatment

Recently we did the necropsy of a 23-week-old fetus (genetic file No. 5225) born after induced abortion. The mother, aged 17, was treated by etretinate for severe psoriasis during 3 years. She discontinued the treatment (0.5 mg/kg) 7 to 8 months before coming pregnant. She was related to her partner...

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Veröffentlicht in:American journal of medical genetics 1990-11, Vol.37 (3), p.437-438
Hauptverfasser: Verloes, Alain, Dodinval, Pol, Koulischer, Lucien, Lambotte, René, Bonnivert, Jacqueline
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container_end_page 438
container_issue 3
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container_title American journal of medical genetics
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creator Verloes, Alain
Dodinval, Pol
Koulischer, Lucien
Lambotte, René
Bonnivert, Jacqueline
description Recently we did the necropsy of a 23-week-old fetus (genetic file No. 5225) born after induced abortion. The mother, aged 17, was treated by etretinate for severe psoriasis during 3 years. She discontinued the treatment (0.5 mg/kg) 7 to 8 months before coming pregnant. She was related to her partner (second cousins, F = 1/64). The fetus weighed 930 g, was 37 cm long, and had an occipitofrontal circumference of 24.5 cm. Face was not considered as unusual. Ears were round and very small, but normally conformed. Meatus were normal. Limbs and spine appeared normal, but X-rays were not available.
doi_str_mv 10.1002/ajmg.1320370333
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subjects fetuses
title Etretinate embrytoxicity 7 months after discontinuation of treatment
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