Specificity of asbestos-induced chromosomal aberrations in short-term cultured human mesothelial cells
Short-term cultured normal human mesothelial cells were exposed for 48 hours to three different asbestos compounds, crocidiolite, chrysotile, and amosite. In the concentration used (0.01 mg/ml) all three asbestiform minerals caused, within a few days, a significant increase of cells showing numerica...
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| Veröffentlicht in: | Cancer genetics and cytogenetics 1989-08, Vol.41 (1), p.33-39 |
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| creator | Olofsson, Kenth Mark, Joachim |
| description | Short-term cultured normal human mesothelial cells were exposed for 48 hours to three different asbestos compounds, crocidiolite, chrysotile, and amosite. In the concentration used (0.01 mg/ml) all three asbestiform minerals caused, within a few days, a significant increase of cells showing numerical and/or structural abnormalities. The abnormalities were analyzed in detail using banding techniques. The results were compared with the cytogenetic observations in 52 published cases of mesotheliomas. This comparison revealed only a few similarities as regards numerical deviations. The structural rearrangements in asbestos-exposed cultures, however, in many instances involved chromosome types and chromosome regions preferentially affected in mesotheliomas. |
| doi_str_mv | 10.1016/0165-4608(89)90105-2 |
| format | Article |
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In the concentration used (0.01 mg/ml) all three asbestiform minerals caused, within a few days, a significant increase of cells showing numerical and/or structural abnormalities. The abnormalities were analyzed in detail using banding techniques. The results were compared with the cytogenetic observations in 52 published cases of mesotheliomas. This comparison revealed only a few similarities as regards numerical deviations. The structural rearrangements in asbestos-exposed cultures, however, in many instances involved chromosome types and chromosome regions preferentially affected in mesotheliomas.</description><subject>Asbestos - adverse effects</subject><subject>Biological and medical sciences</subject><subject>Cells, Cultured</subject><subject>Chemical and industrial products toxicology. Toxic occupational diseases</subject><subject>Chromosome Aberrations</subject><subject>Chromosome Banding</subject><subject>Humans</subject><subject>Karyotyping</subject><subject>Medical sciences</subject><subject>Mesothelioma - etiology</subject><subject>Mesothelioma - genetics</subject><subject>Metals and various inorganic compounds</subject><subject>Pleural Neoplasms - etiology</subject><subject>Pleural Neoplasms - genetics</subject><subject>Toxicology</subject><issn>0165-4608</issn><issn>1873-4456</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1r3DAQhkVoSbZp_kEDPoTSHtxKlvV1KZTQpIVAD23OQpZHrIptbTRyIf--2uyyxx6EDvO8LzMPIe8Y_cQok5_rE20vqf6gzUdDGRVtd0Y2TCve9r2Qr8jmhFyQN4h_KKWqM_KcnHdKyk6wDQm_duBjiD6W5yaFxuEAWBK2cRlXD2PjtznNCdPspsYNkLMrMS3YxKXBbcqlLZDnxq9TWXPFt-vslmYGTGULU6whD9OEb8nr4CaEq-N_SR7vvv2-_d4-_Lz_cfv1ofW95qXVvPeaDWbQgYNQQ-DUd5zpjgfqlKReDZUII5O9EIJLo410Thjdg_JaGn5J3h96dzk9rfUSO0fcb-AWSCtaJpRhQrIK9gfQ54SYIdhdjrPLz5ZRu9dr9-7s3p3Vxr7otV2NXR_712GG8RQ6-qzzm-PcoXdTyG7xEU-YlLWQq4p9OWBQXfyNkC36CEv1HTP4YscU_7_HPx5ylzs</recordid><startdate>19890801</startdate><enddate>19890801</enddate><creator>Olofsson, Kenth</creator><creator>Mark, Joachim</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope></search><sort><creationdate>19890801</creationdate><title>Specificity of asbestos-induced chromosomal aberrations in short-term cultured human mesothelial cells</title><author>Olofsson, Kenth ; Mark, Joachim</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c483t-834c81b9b8f3e57bf30c231823f0a760c7b34cfd164555369896aa5984e7c8693</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>Asbestos - adverse effects</topic><topic>Biological and medical sciences</topic><topic>Cells, Cultured</topic><topic>Chemical and industrial products toxicology. Toxic occupational diseases</topic><topic>Chromosome Aberrations</topic><topic>Chromosome Banding</topic><topic>Humans</topic><topic>Karyotyping</topic><topic>Medical sciences</topic><topic>Mesothelioma - etiology</topic><topic>Mesothelioma - genetics</topic><topic>Metals and various inorganic compounds</topic><topic>Pleural Neoplasms - etiology</topic><topic>Pleural Neoplasms - genetics</topic><topic>Toxicology</topic><toplevel>online_resources</toplevel><creatorcontrib>Olofsson, Kenth</creatorcontrib><creatorcontrib>Mark, Joachim</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><jtitle>Cancer genetics and cytogenetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Olofsson, Kenth</au><au>Mark, Joachim</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Specificity of asbestos-induced chromosomal aberrations in short-term cultured human mesothelial cells</atitle><jtitle>Cancer genetics and cytogenetics</jtitle><addtitle>Cancer Genet Cytogenet</addtitle><date>1989-08-01</date><risdate>1989</risdate><volume>41</volume><issue>1</issue><spage>33</spage><epage>39</epage><pages>33-39</pages><issn>0165-4608</issn><eissn>1873-4456</eissn><coden>CGCYDF</coden><abstract>Short-term cultured normal human mesothelial cells were exposed for 48 hours to three different asbestos compounds, crocidiolite, chrysotile, and amosite. In the concentration used (0.01 mg/ml) all three asbestiform minerals caused, within a few days, a significant increase of cells showing numerical and/or structural abnormalities. The abnormalities were analyzed in detail using banding techniques. The results were compared with the cytogenetic observations in 52 published cases of mesotheliomas. This comparison revealed only a few similarities as regards numerical deviations. The structural rearrangements in asbestos-exposed cultures, however, in many instances involved chromosome types and chromosome regions preferentially affected in mesotheliomas.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>2766251</pmid><doi>10.1016/0165-4608(89)90105-2</doi><tpages>7</tpages></addata></record> |
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| ispartof | Cancer genetics and cytogenetics, 1989-08, Vol.41 (1), p.33-39 |
| issn | 0165-4608 1873-4456 |
| language | eng |
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| source | Elsevier ScienceDirect Journals Complete - AutoHoldings; MEDLINE |
| subjects | Asbestos - adverse effects Biological and medical sciences Cells, Cultured Chemical and industrial products toxicology. Toxic occupational diseases Chromosome Aberrations Chromosome Banding Humans Karyotyping Medical sciences Mesothelioma - etiology Mesothelioma - genetics Metals and various inorganic compounds Pleural Neoplasms - etiology Pleural Neoplasms - genetics Toxicology |
| title | Specificity of asbestos-induced chromosomal aberrations in short-term cultured human mesothelial cells |
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