Activation of group III metabotropic glutamate receptors is neuroprotective in cortical cultures

( RS)-α-Methyl-4-phosphonophenylglycine (MPPG) and ( S)-α-methyl-3-carboxyphenylalanine (M3CPA), two novel preferential antagonists of group III metabotropic glutamate (mGlu) receptors, antagonized the neuroprotective activity of l-2-amino-4-phosphonobutanoate ( l-AP4) or l-serine- O-phosphate in mi...

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Veröffentlicht in:	European journal of pharmacology 1996-08, Vol.310 (1), p.61-66
Hauptverfasser:	Bruno, V., Copani, A., Bonanno, L., Knoepfel, T., Kuhn, R., Roberts, P.J., Nicoletti, F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alanine - analogs & derivatives Alanine - drug effects Alanine - pharmacology Alanine - physiology Animals Biological and medical sciences Cells, Cultured - metabolism Cerebral Cortex - cytology Cerebral Cortex - drug effects Cerebral Cortex - physiology Cortical neuron Excitotoxicity Medical sciences Metabotropic glutamate receptor Mice N-Methylaspartate - toxicity Nerve Degeneration - drug effects Neurons - drug effects Neuropharmacology Neuroprotective agent Pharmacology. Drug treatments Phenylalanine - analogs & derivatives Phenylalanine - drug effects Phenylalanine - pharmacology Phenylalanine - physiology Rabbits Receptors, Metabotropic Glutamate - antagonists & inhibitors Receptors, Metabotropic Glutamate - drug effects Receptors, Metabotropic Glutamate - physiology
Online-Zugang:	Volltext
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