An Epidemiologic Study of Abuse of Analgesic Drugs: Effects of Phenacetin and Salicylate on Mortality and Cardiovascular Morbidity (1968 to 1987)
SINCE it was suggested in 1953 that analgesic drugs could cause chronic renal disease, 1 the relation between prolonged ingestion of such drugs and the development of renal disease has been well studied. 2 3 4 However, none of the investigations were longitudinal, most were case–control studies, and...
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| Veröffentlicht in: | The New England journal of medicine 1991-01, Vol.324 (3), p.155-160 |
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| container_title | The New England journal of medicine |
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| creator | Dubach, Ulrich C Rosner, Bernard Stürmer, Til |
| description | SINCE it was suggested in 1953 that analgesic drugs could cause chronic renal disease,
1
the relation between prolonged ingestion of such drugs and the development of renal disease has been well studied.
2
3
4
However, none of the investigations were longitudinal, most were case–control studies, and few used objective measures of drug use. As a result, none clearly demonstrated whether excessive or prolonged use of analgesic agents by healthy persons causes renal disorders.
5
In 1967 we designed the present study to determine the incidence of renal disease among 623 apparently healthy women 30 to 49 years old who regularly took analgesic drugs . . . |
| doi_str_mv | 10.1056/NEJM199101173240304 |
| format | Article |
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1
the relation between prolonged ingestion of such drugs and the development of renal disease has been well studied.
2
3
4
However, none of the investigations were longitudinal, most were case–control studies, and few used objective measures of drug use. As a result, none clearly demonstrated whether excessive or prolonged use of analgesic agents by healthy persons causes renal disorders.
5
In 1967 we designed the present study to determine the incidence of renal disease among 623 apparently healthy women 30 to 49 years old who regularly took analgesic drugs . . .</description><identifier>ISSN: 0028-4793</identifier><identifier>EISSN: 1533-4406</identifier><identifier>DOI: 10.1056/NEJM199101173240304</identifier><identifier>PMID: 1984193</identifier><identifier>CODEN: NEJMAG</identifier><language>eng</language><publisher>Boston, MA: Massachusetts Medical Society</publisher><subject>Abuse ; Adult ; Aged ; Analgesics ; Aspirin - adverse effects ; Biological and medical sciences ; Cancer ; Cardiovascular disease ; Cardiovascular diseases ; Cardiovascular Diseases - epidemiology ; Cardiovascular Diseases - mortality ; Cerebral infarction ; Cigarette smoking ; Dose-Response Relationship, Drug ; Drug abuse ; Drug intoxications. Doping ; Drugs ; Epidemiology ; Excretion ; Female ; Health risk assessment ; Heart ; Heart diseases ; Humans ; Hypertension ; Hypertension - epidemiology ; Kidney diseases ; Kidney Diseases - mortality ; Laboratories ; Longitudinal Studies ; Medical sciences ; Metabolites ; Middle Aged ; Morbidity ; Mortality ; Myocardial infarction ; Neoplasms - mortality ; Pharmacology. Drug treatments ; Phenacetin ; Phenacetin - adverse effects ; Prospective Studies ; Risk ; Salicylic acid ; Substance-Related Disorders ; Urine ; Urologic Diseases - mortality ; Womens health</subject><ispartof>The New England journal of medicine, 1991-01, Vol.324 (3), p.155-160</ispartof><rights>1993 INIST-CNRS</rights><rights>Copyright Massachusetts Medical Society Jan 17, 1991</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c434t-6b3171c2e0db93aa38c88316238e0f3f88756203c0266c6e9c7f5cbb483358853</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.nejm.org/doi/pdf/10.1056/NEJM199101173240304$$EPDF$$P50$$Gmms$$H</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/1983431898?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,780,784,2757,2758,26102,27923,27924,52381,54063,64384,64386,64388,72240</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4453974$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1984193$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dubach, Ulrich C</creatorcontrib><creatorcontrib>Rosner, Bernard</creatorcontrib><creatorcontrib>Stürmer, Til</creatorcontrib><title>An Epidemiologic Study of Abuse of Analgesic Drugs: Effects of Phenacetin and Salicylate on Mortality and Cardiovascular Morbidity (1968 to 1987)</title><title>The New England journal of medicine</title><addtitle>N Engl J Med</addtitle><description>SINCE it was suggested in 1953 that analgesic drugs could cause chronic renal disease,
1
the relation between prolonged ingestion of such drugs and the development of renal disease has been well studied.
2
3
4
However, none of the investigations were longitudinal, most were case–control studies, and few used objective measures of drug use. As a result, none clearly demonstrated whether excessive or prolonged use of analgesic agents by healthy persons causes renal disorders.
5
In 1967 we designed the present study to determine the incidence of renal disease among 623 apparently healthy women 30 to 49 years old who regularly took analgesic drugs . . .</description><subject>Abuse</subject><subject>Adult</subject><subject>Aged</subject><subject>Analgesics</subject><subject>Aspirin - adverse effects</subject><subject>Biological and medical sciences</subject><subject>Cancer</subject><subject>Cardiovascular disease</subject><subject>Cardiovascular diseases</subject><subject>Cardiovascular Diseases - epidemiology</subject><subject>Cardiovascular Diseases - mortality</subject><subject>Cerebral infarction</subject><subject>Cigarette smoking</subject><subject>Dose-Response Relationship, Drug</subject><subject>Drug abuse</subject><subject>Drug intoxications. Doping</subject><subject>Drugs</subject><subject>Epidemiology</subject><subject>Excretion</subject><subject>Female</subject><subject>Health risk assessment</subject><subject>Heart</subject><subject>Heart diseases</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Hypertension - epidemiology</subject><subject>Kidney diseases</subject><subject>Kidney Diseases - mortality</subject><subject>Laboratories</subject><subject>Longitudinal Studies</subject><subject>Medical sciences</subject><subject>Metabolites</subject><subject>Middle Aged</subject><subject>Morbidity</subject><subject>Mortality</subject><subject>Myocardial infarction</subject><subject>Neoplasms - mortality</subject><subject>Pharmacology. Drug treatments</subject><subject>Phenacetin</subject><subject>Phenacetin - adverse effects</subject><subject>Prospective Studies</subject><subject>Risk</subject><subject>Salicylic acid</subject><subject>Substance-Related Disorders</subject><subject>Urine</subject><subject>Urologic Diseases - mortality</subject><subject>Womens health</subject><issn>0028-4793</issn><issn>1533-4406</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp9kFtLAzEQhYMoWqu_QISC4ousJplcH0utN6o-qM9LNpstW_ZSk-5D_72pWxREnJcZON-cGQ5CJwRfEczF9fP08YloTTAhEijDgNkOGhAOkDCGxS4aYExVwqSGA3QYwgLHIkzvo32iFSMaBoiOm9F0WeauLtuqnZd29Lrq8vWoLUbjrAvua2hMNXchaje-m4cjtFeYKrjjbR-i99vp2-Q-mb3cPUzGs8QyYKtEZEAksdThPNNgDCirFBBBQTlcQKGU5IJisJgKYYXTVhbcZhlTAFwpDkN00fsuffvRubBK6zJYV1WmcW0XUsKlEpJCBM9-gYu28_HpyGgFDIiKbYigp6xvQ_CuSJe-rI1fpwSnmzzTP_KMW6db7y6rXf6z0wcY9fOtboI1VeFNY8vwjTHGQcuNzWWP1XVIG7eo_z36CUaghRU</recordid><startdate>19910117</startdate><enddate>19910117</enddate><creator>Dubach, Ulrich C</creator><creator>Rosner, Bernard</creator><creator>Stürmer, Til</creator><general>Massachusetts Medical Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0TZ</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K0Y</scope><scope>LK8</scope><scope>M0R</scope><scope>M0T</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>M2P</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7T2</scope><scope>7U2</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>19910117</creationdate><title>An Epidemiologic Study of Abuse of Analgesic Drugs</title><author>Dubach, Ulrich C ; Rosner, Bernard ; Stürmer, Til</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c434t-6b3171c2e0db93aa38c88316238e0f3f88756203c0266c6e9c7f5cbb483358853</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>Abuse</topic><topic>Adult</topic><topic>Aged</topic><topic>Analgesics</topic><topic>Aspirin - adverse effects</topic><topic>Biological and medical sciences</topic><topic>Cancer</topic><topic>Cardiovascular disease</topic><topic>Cardiovascular diseases</topic><topic>Cardiovascular Diseases - epidemiology</topic><topic>Cardiovascular Diseases - mortality</topic><topic>Cerebral infarction</topic><topic>Cigarette smoking</topic><topic>Dose-Response Relationship, Drug</topic><topic>Drug abuse</topic><topic>Drug intoxications. Doping</topic><topic>Drugs</topic><topic>Epidemiology</topic><topic>Excretion</topic><topic>Female</topic><topic>Health risk assessment</topic><topic>Heart</topic><topic>Heart diseases</topic><topic>Humans</topic><topic>Hypertension</topic><topic>Hypertension - epidemiology</topic><topic>Kidney diseases</topic><topic>Kidney Diseases - mortality</topic><topic>Laboratories</topic><topic>Longitudinal Studies</topic><topic>Medical sciences</topic><topic>Metabolites</topic><topic>Middle Aged</topic><topic>Morbidity</topic><topic>Mortality</topic><topic>Myocardial infarction</topic><topic>Neoplasms - mortality</topic><topic>Pharmacology. Drug treatments</topic><topic>Phenacetin</topic><topic>Phenacetin - adverse effects</topic><topic>Prospective Studies</topic><topic>Risk</topic><topic>Salicylic acid</topic><topic>Substance-Related Disorders</topic><topic>Urine</topic><topic>Urologic Diseases - mortality</topic><topic>Womens health</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dubach, Ulrich C</creatorcontrib><creatorcontrib>Rosner, Bernard</creatorcontrib><creatorcontrib>Stürmer, Til</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Pharma and Biotech Premium PRO</collection><collection>Proquest Nursing & Allied Health Source</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>eLibrary</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>New England Journal of Medicine</collection><collection>ProQuest Biological Science Collection</collection><collection>Consumer Health Database</collection><collection>Healthcare Administration Database</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>Research Library</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Safety Science and Risk</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>The New England journal of medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dubach, Ulrich C</au><au>Rosner, Bernard</au><au>Stürmer, Til</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>An Epidemiologic Study of Abuse of Analgesic Drugs: Effects of Phenacetin and Salicylate on Mortality and Cardiovascular Morbidity (1968 to 1987)</atitle><jtitle>The New England journal of medicine</jtitle><addtitle>N Engl J Med</addtitle><date>1991-01-17</date><risdate>1991</risdate><volume>324</volume><issue>3</issue><spage>155</spage><epage>160</epage><pages>155-160</pages><issn>0028-4793</issn><eissn>1533-4406</eissn><coden>NEJMAG</coden><abstract>SINCE it was suggested in 1953 that analgesic drugs could cause chronic renal disease,
1
the relation between prolonged ingestion of such drugs and the development of renal disease has been well studied.
2
3
4
However, none of the investigations were longitudinal, most were case–control studies, and few used objective measures of drug use. As a result, none clearly demonstrated whether excessive or prolonged use of analgesic agents by healthy persons causes renal disorders.
5
In 1967 we designed the present study to determine the incidence of renal disease among 623 apparently healthy women 30 to 49 years old who regularly took analgesic drugs . . .</abstract><cop>Boston, MA</cop><pub>Massachusetts Medical Society</pub><pmid>1984193</pmid><doi>10.1056/NEJM199101173240304</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0028-4793 |
| ispartof | The New England journal of medicine, 1991-01, Vol.324 (3), p.155-160 |
| issn | 0028-4793 1533-4406 |
| language | eng |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; ProQuest Central UK/Ireland; New England Journal of Medicine |
| subjects | Abuse Adult Aged Analgesics Aspirin - adverse effects Biological and medical sciences Cancer Cardiovascular disease Cardiovascular diseases Cardiovascular Diseases - epidemiology Cardiovascular Diseases - mortality Cerebral infarction Cigarette smoking Dose-Response Relationship, Drug Drug abuse Drug intoxications. Doping Drugs Epidemiology Excretion Female Health risk assessment Heart Heart diseases Humans Hypertension Hypertension - epidemiology Kidney diseases Kidney Diseases - mortality Laboratories Longitudinal Studies Medical sciences Metabolites Middle Aged Morbidity Mortality Myocardial infarction Neoplasms - mortality Pharmacology. Drug treatments Phenacetin Phenacetin - adverse effects Prospective Studies Risk Salicylic acid Substance-Related Disorders Urine Urologic Diseases - mortality Womens health |
| title | An Epidemiologic Study of Abuse of Analgesic Drugs: Effects of Phenacetin and Salicylate on Mortality and Cardiovascular Morbidity (1968 to 1987) |
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