The effects of inhibitors of arachidonate metabolism on spontaneous and evoked endplate potentials at normal and crotoxin-treated frog neuromuscular junctions

Aspirin (1 mM), a selective cyclooxygenase inhibitor, decreased endplate potential (e.p.p.) amplitude but did not affect either the biphasic changes in m.e.p.p. frequency or triphasic changes in e.p.p. amplitude induced by crotoxin. Nordihydroguaiaretic acid (30 μM), a dual inhibitor of cyclooxygena...

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Veröffentlicht in:	Toxicon (Oxford) 1990, Vol.28 (8), p.985-988
Hauptverfasser:	Edwards, Jonathon, Hawgood, Barbara J., Smith, I.Christopher H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal poisons toxicology. Antivenoms Animals Arachidonic Acid Arachidonic Acids - metabolism Aspirin - pharmacology Biological and medical sciences Crotoxin - toxicity Evoked Potentials - drug effects In Vitro Techniques Masoprocol - pharmacology Medical sciences Motor Endplate - drug effects Neuromuscular Junction - drug effects Rana temporaria Toxicology
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