Development of a Class of Selective Cholecystokinin Type B Receptor Antagonists Having Potent Anxiolytic Activity

PD134308 and PD135158 are potent and selective antagonists at the cholecystokinin type B (CCK-B) receptors with IC50values of 1.6 nM and 3.5 nM, respectively, in the radioligand binding assay and Kevalues of 7.82 and 12.9 nM, respectively, in their blocking action on CCK responses in the rat lateral...

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