Mutagenesis of the human IgA1 heavy chain tailpiece that prevents dimer assembly

The structural features of the human IgA1 tailpiece required for interaction with J chain in IgA dimer assembly were investigated using a protein engineering approach. Wild-type and mutant forms of IgA1 were expressed in the mouse myeloma cell line, J558L, which endogenously expresses J chain. Wild-...

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Veröffentlicht in:	The Journal of immunology (1950) 1996-07, Vol.157 (1), p.156-159
Hauptverfasser:	Atkin, JD, Pleass, RJ, Owens, RJ, Woof, JM
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Base Sequence Biopolymers - biosynthesis Biopolymers - genetics Biopolymers - immunology Genetic Vectors - immunology Humans Immunoglobulin A - biosynthesis Immunoglobulin A - chemistry Immunoglobulin A - genetics Mice Molecular Sequence Data Mutagenesis, Site-Directed - immunology Protein Conformation Protein Engineering Recombinant Proteins - biosynthesis Recombinant Proteins - chemistry Tumor Cells, Cultured
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