An analysis of experimental radiation carcinogenesis with model setting for competing risks

An analysis of experimental radiation carcinogenesis with model setting for competing risks

The mean life span of animals killed by a specific type of tumor and the incidence of that particular tumor are influenced by competing risks. A parametric approach for censored samples was applied to correct for the competing risks. The life span distribution under each risk wherein the other risks...

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Veröffentlicht in:Journal of radiation research 1990-06, Vol.31 (2), p.147-155
Hauptverfasser: Sato, F, Noda, K, Kato, H, Murakami, M, Endoh, D, Hashimoto, N
Format: Artikel
Sprache:eng
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Animals
Data Interpretation, Statistical
Female
Mice
Neoplasms, Experimental - mortality
Neoplasms, Radiation-Induced - mortality
Risk
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container_end_page 155
container_issue 2
container_start_page 147
container_title Journal of radiation research
container_volume 31
creator Sato, F
Noda, K
Kato, H
Murakami, M
Endoh, D
Hashimoto, N
description The mean life span of animals killed by a specific type of tumor and the incidence of that particular tumor are influenced by competing risks. A parametric approach for censored samples was applied to correct for the competing risks. The life span distribution under each risk wherein the other risks were thought to be eliminated is assumed to be a Weibull distribution. Our data were from an experiment on tumor induction by X-rays in mice: whole body irradiation with 600 R; head with 800 R; trunk with 800 R; or lower body with 800 R. Analysis of the results shows that the mean appearance time of malignant lymphomas was accelerated by whole body irradiation. Acceleration of lung tumors was relatively large after trunk irradiation. Mammary tumors were accelerated by whole body, trunk or lower body irradiation.
doi_str_mv 10.1269/jrr.31.147
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source Freely Accessible Japanese Titles (ERDB Project); Oxford Journals Open Access Collection; J-STAGE (Free - Japanese); MEDLINE; Free Full-Text Journals in Chemistry; EZB Electronic Journals Library
subjects Animals
Data Interpretation, Statistical
Female
Mice
Neoplasms, Experimental - mortality
Neoplasms, Radiation-Induced - mortality
Risk
title An analysis of experimental radiation carcinogenesis with model setting for competing risks
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