Differential effects of sodium butyrate and hyperosmolality on the modulation of alkaline phosphatases of LoVo cells
LoVo cells produce term-placental and intestinal alkaline phosphatases. Hyperosmolality and sodium butyrate increase the levels of both, but the effect of sodium butyrate is more pronounced on the intestinal enzyme. When applied together, induction of term-placental alkaline phosphatase is additive...
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| Veröffentlicht in: | Experimental cell research 1990-05, Vol.188 (1), p.50-54 |
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| creator | Herz, Fritz Halwer, Murray |
| description | LoVo cells produce term-placental and intestinal alkaline phosphatases. Hyperosmolality and sodium butyrate increase the levels of both, but the effect of sodium butyrate is more pronounced on the intestinal enzyme. When applied together, induction of term-placental alkaline phosphatase is additive and that of the intestinal enzyme is synergistic. Induction by either stimulus or by their mixture is independent of cell density. However, whereas the effect of hyperosmolality is readily reversible, induction by sodium butyrate is not. No synergistic increase in intestinal alkaline phosphatase activity occurs when cells are sequentially treated with hyperosmolality and sodium butyrate or vice versa. This indicates that only when applied concurrently does one inducer amplify the effect of the other. Since the normal colonic mucosa produces intestinal alkaline phosphatase, its predominant induction by sodium butyrate in LoVo cells may reflect a more differentiated state. |
| doi_str_mv | 10.1016/0014-4827(90)90276-G |
| format | Article |
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Hyperosmolality and sodium butyrate increase the levels of both, but the effect of sodium butyrate is more pronounced on the intestinal enzyme. When applied together, induction of term-placental alkaline phosphatase is additive and that of the intestinal enzyme is synergistic. Induction by either stimulus or by their mixture is independent of cell density. However, whereas the effect of hyperosmolality is readily reversible, induction by sodium butyrate is not. No synergistic increase in intestinal alkaline phosphatase activity occurs when cells are sequentially treated with hyperosmolality and sodium butyrate or vice versa. This indicates that only when applied concurrently does one inducer amplify the effect of the other. 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Hyperosmolality and sodium butyrate increase the levels of both, but the effect of sodium butyrate is more pronounced on the intestinal enzyme. When applied together, induction of term-placental alkaline phosphatase is additive and that of the intestinal enzyme is synergistic. Induction by either stimulus or by their mixture is independent of cell density. However, whereas the effect of hyperosmolality is readily reversible, induction by sodium butyrate is not. No synergistic increase in intestinal alkaline phosphatase activity occurs when cells are sequentially treated with hyperosmolality and sodium butyrate or vice versa. This indicates that only when applied concurrently does one inducer amplify the effect of the other. Since the normal colonic mucosa produces intestinal alkaline phosphatase, its predominant induction by sodium butyrate in LoVo cells may reflect a more differentiated state.</description><subject>Alkaline Phosphatase - metabolism</subject><subject>Analytical, structural and metabolic biochemistry</subject><subject>Biological and medical sciences</subject><subject>Butyrates - pharmacology</subject><subject>Butyric Acid</subject><subject>Carcinoma - enzymology</subject><subject>Carcinoma - pathology</subject><subject>Child</subject><subject>Colonic Neoplasms - enzymology</subject><subject>Colonic Neoplasms - pathology</subject><subject>Enzymes and enzyme inhibitors</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Osmolar Concentration</subject><subject>osmotic pressure</subject><subject>sodium butyrate</subject><subject>Tumor Cells, Cultured - drug effects</subject><subject>Tumor Cells, Cultured - enzymology</subject><subject>Tumor Cells, Cultured - pathology</subject><issn>0014-4827</issn><issn>1090-2422</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kUGv1CAUhYnRPMen_0ATFsboogotBboxMU8dTSZxo27JHbhk0LZUoCbz72XeTGbpCsj5zs25B0Kec_aWMy7fMcZFI3SrXg_szcBaJZvtA7LhbGBNK9r2IdlckcfkSc6_GGNac3lDbtqu1UqpDSkfg_eYcC4BRor1bkum0dMcXVgnul_LMUFBCrOjh-OCKeYpjjCGcqRxpuWAdIpuHaGE-qxGGH9XdUa6HGJeDlAg4_3EXfwZqcVxzE_JIw9jxmeX85b8-Pzp-92XZvdt-_Xuw66xnZalcT3zimtouZa-8yA1gHS9t2AZghQcndBSdFI7O-yFl50eHOt1L9zgrIbulrw6z11S_LNiLmYK-ZQAZoxrNrxXUnVcVFCcQVvXywm9WVKYIB0NZ-ZUtjk1aU5NmoGZ-7LNttpeXOav-wnd1XRpt-ovLzpkC6NPMNuQr1hNLoTiFXt_xrB28TdgMtkGnC26kOp3GBfD_3P8A6FDnV4</recordid><startdate>19900501</startdate><enddate>19900501</enddate><creator>Herz, Fritz</creator><creator>Halwer, Murray</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>M81</scope><scope>P64</scope></search><sort><creationdate>19900501</creationdate><title>Differential effects of sodium butyrate and hyperosmolality on the modulation of alkaline phosphatases of LoVo cells</title><author>Herz, Fritz ; Halwer, Murray</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c386t-d50f718a2186f3fa68aa6d5fcac0ea641ed4864368dc9b4f6389d05854d9dc8a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Alkaline Phosphatase - metabolism</topic><topic>Analytical, structural and metabolic biochemistry</topic><topic>Biological and medical sciences</topic><topic>Butyrates - pharmacology</topic><topic>Butyric Acid</topic><topic>Carcinoma - enzymology</topic><topic>Carcinoma - pathology</topic><topic>Child</topic><topic>Colonic Neoplasms - enzymology</topic><topic>Colonic Neoplasms - pathology</topic><topic>Enzymes and enzyme inhibitors</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>Osmolar Concentration</topic><topic>osmotic pressure</topic><topic>sodium butyrate</topic><topic>Tumor Cells, Cultured - drug effects</topic><topic>Tumor Cells, Cultured - enzymology</topic><topic>Tumor Cells, Cultured - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Herz, Fritz</creatorcontrib><creatorcontrib>Halwer, Murray</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biochemistry Abstracts 3</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Experimental cell research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Herz, Fritz</au><au>Halwer, Murray</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Differential effects of sodium butyrate and hyperosmolality on the modulation of alkaline phosphatases of LoVo cells</atitle><jtitle>Experimental cell research</jtitle><addtitle>Exp Cell Res</addtitle><date>1990-05-01</date><risdate>1990</risdate><volume>188</volume><issue>1</issue><spage>50</spage><epage>54</epage><pages>50-54</pages><issn>0014-4827</issn><eissn>1090-2422</eissn><coden>ECREAL</coden><abstract>LoVo cells produce term-placental and intestinal alkaline phosphatases. Hyperosmolality and sodium butyrate increase the levels of both, but the effect of sodium butyrate is more pronounced on the intestinal enzyme. When applied together, induction of term-placental alkaline phosphatase is additive and that of the intestinal enzyme is synergistic. Induction by either stimulus or by their mixture is independent of cell density. However, whereas the effect of hyperosmolality is readily reversible, induction by sodium butyrate is not. No synergistic increase in intestinal alkaline phosphatase activity occurs when cells are sequentially treated with hyperosmolality and sodium butyrate or vice versa. This indicates that only when applied concurrently does one inducer amplify the effect of the other. 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| ispartof | Experimental cell research, 1990-05, Vol.188 (1), p.50-54 |
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| subjects | Alkaline Phosphatase - metabolism Analytical, structural and metabolic biochemistry Biological and medical sciences Butyrates - pharmacology Butyric Acid Carcinoma - enzymology Carcinoma - pathology Child Colonic Neoplasms - enzymology Colonic Neoplasms - pathology Enzymes and enzyme inhibitors Fundamental and applied biological sciences. Psychology Humans Osmolar Concentration osmotic pressure sodium butyrate Tumor Cells, Cultured - drug effects Tumor Cells, Cultured - enzymology Tumor Cells, Cultured - pathology |
| title | Differential effects of sodium butyrate and hyperosmolality on the modulation of alkaline phosphatases of LoVo cells |
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