The protective role of zinc and N-acetylcysteine in modulating zidovudine induced hematopoietic toxicity

The role of zinc and N-acetylcysteine (NAC) has been investigated in protecting the hematopoietic progenitor cells from zidovudine (AZT)-induced toxicity. Murine bone marrow progenitor cells (BMPC, 1 × 10 6) were exposed to various concentrations (0.1–50 μM) of AZT in the presence and absence of zin...

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Veröffentlicht in:	Life sciences (1973) 1996, Vol.59 (16), p.1323-1329
Hauptverfasser:	Gogu, Sudhir R., Agrawal, Krishna C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcysteine - pharmacology Acetylcysteine - therapeutic use Animals Antidotes - pharmacology Antidotes - therapeutic use Bone Marrow - drug effects Cell Survival - drug effects Female hematopoiesis Hematopoietic Stem Cells - cytology metallothionein Mice N-acetylcysteine Zidovudine - adverse effects zidovudine toxicity zinc Zinc - pharmacology Zinc - therapeutic use
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