EFFECTS OF INGESTED LEAD ON ANTIBODY PRODUCTION IN MALLARDS (ANAS PLATYRHYNCHOS)
We examined the effects of lead ingestion on in vitro and in vivo indices of immune function in mallards (Anas platyrhynchos). Twenty-four mallard drakes were randomly divided into three groups (I, II, III), then assigned to treatment or control subgroups (n = 4). On day 0, all treatment birds were...
Gespeichert in:
| Veröffentlicht in: | Journal of wildlife diseases 1990-07, Vol.26 (3), p.316-322 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 322 |
|---|---|
| container_issue | 3 |
| container_start_page | 316 |
| container_title | Journal of wildlife diseases |
| container_volume | 26 |
| creator | Trust, Kimberly A. Miller, Michael W. Ringelman, James K. Orme, Ian M. |
| description | We examined the effects of lead ingestion on in vitro and in vivo indices of immune function in mallards (Anas platyrhynchos). Twenty-four mallard drakes were randomly divided into three groups (I, II, III), then assigned to treatment or control subgroups (n = 4). On day 0, all treatment birds were dosed orally with one number 4 lead shot (x̄ = 0.2 g). We challenged all individuals in each group with washed sheep red blood cells (SRBC) injected intraperitoneally on days 0 (Group I), 7 (Group II) or 14 (Group III), and collected blood for analyses 7 and 8 days after SRBC challenge. We measured and compared blood lead concentrations, in vitro lymphocyte transformation responses to phytohemagglutinin A and lipopolysaccharide, and hemagglutination titers to SRBC. Mean blood lead concentrations were elevated (P ≤ 0.04) in treatment birds at each sampling period. Large individual variability in lymphocyte stimulation responses precluded further analysis of those data. Hemagglutination titers to SRBC were lower (P < 0.0001) in lead-poisoned ducks than in controls, suggesting that ingested lead may have immunosuppressive effects on mallards. |
| doi_str_mv | 10.7589/0090-3558-26.3.316 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_15763402</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>15763402</sourcerecordid><originalsourceid>FETCH-LOGICAL-b419t-bfc8a60a5053b38f67e0d8d9e884b39495c442a2436da79a00cc701f3e9113dc3</originalsourceid><addsrcrecordid>eNqNkE9vmzAYh61pU5d1-wKVJvmyaTuQ-S_YRwakQWIQBXLIyTJgWiZSWtwo6revI6Jqx50s-_e8P71-ALjBaBlwIX8hJJFHORce8Zd0SbH_DiywZNSjAULvweIN-Ag-WfsXIcLd5QpcESoE5WwBNslqlURVCYsVTPPbpKySGGZJGMMih2Fepb-LeA832yLeRVXq3tIc_gmzLNzGJfwR5mEJN1lY7bfrfR6ti_LnZ_Ch04M1Xy7nNditkipae1lxm0Zh5tUMy2ev7hqhfaQ54rSmovMDg1rRSiMEq6lkkjeMEU0Y9VsdSI1Q0wQId9RIjGnb0Gvwfe59nMano7HP6tDbxgyDfjDj0SrMA58yRBxIZrCZRmsn06nHqT_o6UVhpM4a1dmSOltSxFdUOY1u6Oul_VgfTPs2cvHm8m9zft_f3Z_6ySh70MPgaKJOp9M_PTcz1-lR6bupt2pXSkzc36QL0RzW_Tg-mP_Z6xUnBYib</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>15763402</pqid></control><display><type>article</type><title>EFFECTS OF INGESTED LEAD ON ANTIBODY PRODUCTION IN MALLARDS (ANAS PLATYRHYNCHOS)</title><source>MEDLINE</source><source>BioOne Open Access Titles</source><source>Allen Press Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><creator>Trust, Kimberly A. ; Miller, Michael W. ; Ringelman, James K. ; Orme, Ian M.</creator><creatorcontrib>Trust, Kimberly A. ; Miller, Michael W. ; Ringelman, James K. ; Orme, Ian M.</creatorcontrib><description>We examined the effects of lead ingestion on in vitro and in vivo indices of immune function in mallards (Anas platyrhynchos). Twenty-four mallard drakes were randomly divided into three groups (I, II, III), then assigned to treatment or control subgroups (n = 4). On day 0, all treatment birds were dosed orally with one number 4 lead shot (x̄ = 0.2 g). We challenged all individuals in each group with washed sheep red blood cells (SRBC) injected intraperitoneally on days 0 (Group I), 7 (Group II) or 14 (Group III), and collected blood for analyses 7 and 8 days after SRBC challenge. We measured and compared blood lead concentrations, in vitro lymphocyte transformation responses to phytohemagglutinin A and lipopolysaccharide, and hemagglutination titers to SRBC. Mean blood lead concentrations were elevated (P ≤ 0.04) in treatment birds at each sampling period. Large individual variability in lymphocyte stimulation responses precluded further analysis of those data. Hemagglutination titers to SRBC were lower (P < 0.0001) in lead-poisoned ducks than in controls, suggesting that ingested lead may have immunosuppressive effects on mallards.</description><identifier>ISSN: 0090-3558</identifier><identifier>EISSN: 1943-3700</identifier><identifier>DOI: 10.7589/0090-3558-26.3.316</identifier><identifier>PMID: 2388354</identifier><language>eng</language><publisher>United States: Wildlife Disease Association</publisher><subject>Anas platyrhynchos ; Animals ; Antibody Formation - drug effects ; Bird Diseases - immunology ; Body Weight - drug effects ; Brackish ; CANARD ; DEFICIENCE IMMUNOLOGIQUE ; DEFICIENCIA INMUNOLOGICA ; DUCKS ; Ducks - immunology ; experimental study ; Freshwater ; hemagglutination ; Hemagglutination - drug effects ; IMMUNE RESPONSE ; Immune Tolerance - drug effects ; IMMUNOLOGICAL DEFICIENCY ; immunosuppression ; intoxication ; LEAD ; Lead - blood ; Lead - toxicity ; Lead Poisoning - immunology ; Lead Poisoning - veterinary ; Lymphocyte Activation - drug effects ; lymphocyte transformation ; Male ; mallard ; Marine ; PATO ; PLOMB ; PLOMO ; Random Allocation ; REPONSE IMMUNITAIRE ; RESPUESTA INMUNOLOGICA</subject><ispartof>Journal of wildlife diseases, 1990-07, Vol.26 (3), p.316-322</ispartof><rights>Wildlife Disease Association 1990</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b419t-bfc8a60a5053b38f67e0d8d9e884b39495c442a2436da79a00cc701f3e9113dc3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://bioone.org/doi/pdf/10.7589/0090-3558-26.3.316$$EPDF$$P50$$Gbioone$$H</linktopdf><link.rule.ids>109,314,780,784,27924,27925,52719</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2388354$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Trust, Kimberly A.</creatorcontrib><creatorcontrib>Miller, Michael W.</creatorcontrib><creatorcontrib>Ringelman, James K.</creatorcontrib><creatorcontrib>Orme, Ian M.</creatorcontrib><title>EFFECTS OF INGESTED LEAD ON ANTIBODY PRODUCTION IN MALLARDS (ANAS PLATYRHYNCHOS)</title><title>Journal of wildlife diseases</title><addtitle>J Wildl Dis</addtitle><description>We examined the effects of lead ingestion on in vitro and in vivo indices of immune function in mallards (Anas platyrhynchos). Twenty-four mallard drakes were randomly divided into three groups (I, II, III), then assigned to treatment or control subgroups (n = 4). On day 0, all treatment birds were dosed orally with one number 4 lead shot (x̄ = 0.2 g). We challenged all individuals in each group with washed sheep red blood cells (SRBC) injected intraperitoneally on days 0 (Group I), 7 (Group II) or 14 (Group III), and collected blood for analyses 7 and 8 days after SRBC challenge. We measured and compared blood lead concentrations, in vitro lymphocyte transformation responses to phytohemagglutinin A and lipopolysaccharide, and hemagglutination titers to SRBC. Mean blood lead concentrations were elevated (P ≤ 0.04) in treatment birds at each sampling period. Large individual variability in lymphocyte stimulation responses precluded further analysis of those data. Hemagglutination titers to SRBC were lower (P < 0.0001) in lead-poisoned ducks than in controls, suggesting that ingested lead may have immunosuppressive effects on mallards.</description><subject>Anas platyrhynchos</subject><subject>Animals</subject><subject>Antibody Formation - drug effects</subject><subject>Bird Diseases - immunology</subject><subject>Body Weight - drug effects</subject><subject>Brackish</subject><subject>CANARD</subject><subject>DEFICIENCE IMMUNOLOGIQUE</subject><subject>DEFICIENCIA INMUNOLOGICA</subject><subject>DUCKS</subject><subject>Ducks - immunology</subject><subject>experimental study</subject><subject>Freshwater</subject><subject>hemagglutination</subject><subject>Hemagglutination - drug effects</subject><subject>IMMUNE RESPONSE</subject><subject>Immune Tolerance - drug effects</subject><subject>IMMUNOLOGICAL DEFICIENCY</subject><subject>immunosuppression</subject><subject>intoxication</subject><subject>LEAD</subject><subject>Lead - blood</subject><subject>Lead - toxicity</subject><subject>Lead Poisoning - immunology</subject><subject>Lead Poisoning - veterinary</subject><subject>Lymphocyte Activation - drug effects</subject><subject>lymphocyte transformation</subject><subject>Male</subject><subject>mallard</subject><subject>Marine</subject><subject>PATO</subject><subject>PLOMB</subject><subject>PLOMO</subject><subject>Random Allocation</subject><subject>REPONSE IMMUNITAIRE</subject><subject>RESPUESTA INMUNOLOGICA</subject><issn>0090-3558</issn><issn>1943-3700</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkE9vmzAYh61pU5d1-wKVJvmyaTuQ-S_YRwakQWIQBXLIyTJgWiZSWtwo6revI6Jqx50s-_e8P71-ALjBaBlwIX8hJJFHORce8Zd0SbH_DiywZNSjAULvweIN-Ag-WfsXIcLd5QpcESoE5WwBNslqlURVCYsVTPPbpKySGGZJGMMih2Fepb-LeA832yLeRVXq3tIc_gmzLNzGJfwR5mEJN1lY7bfrfR6ti_LnZ_Ch04M1Xy7nNditkipae1lxm0Zh5tUMy2ev7hqhfaQ54rSmovMDg1rRSiMEq6lkkjeMEU0Y9VsdSI1Q0wQId9RIjGnb0Gvwfe59nMano7HP6tDbxgyDfjDj0SrMA58yRBxIZrCZRmsn06nHqT_o6UVhpM4a1dmSOltSxFdUOY1u6Oul_VgfTPs2cvHm8m9zft_f3Z_6ySh70MPgaKJOp9M_PTcz1-lR6bupt2pXSkzc36QL0RzW_Tg-mP_Z6xUnBYib</recordid><startdate>19900701</startdate><enddate>19900701</enddate><creator>Trust, Kimberly A.</creator><creator>Miller, Michael W.</creator><creator>Ringelman, James K.</creator><creator>Orme, Ian M.</creator><general>Wildlife Disease Association</general><general>Wildlife Dis Assoc</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7U7</scope><scope>C1K</scope><scope>F1W</scope><scope>H94</scope><scope>H95</scope><scope>H97</scope><scope>H98</scope><scope>L.G</scope></search><sort><creationdate>19900701</creationdate><title>EFFECTS OF INGESTED LEAD ON ANTIBODY PRODUCTION IN MALLARDS (ANAS PLATYRHYNCHOS)</title><author>Trust, Kimberly A. ; Miller, Michael W. ; Ringelman, James K. ; Orme, Ian M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b419t-bfc8a60a5053b38f67e0d8d9e884b39495c442a2436da79a00cc701f3e9113dc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Anas platyrhynchos</topic><topic>Animals</topic><topic>Antibody Formation - drug effects</topic><topic>Bird Diseases - immunology</topic><topic>Body Weight - drug effects</topic><topic>Brackish</topic><topic>CANARD</topic><topic>DEFICIENCE IMMUNOLOGIQUE</topic><topic>DEFICIENCIA INMUNOLOGICA</topic><topic>DUCKS</topic><topic>Ducks - immunology</topic><topic>experimental study</topic><topic>Freshwater</topic><topic>hemagglutination</topic><topic>Hemagglutination - drug effects</topic><topic>IMMUNE RESPONSE</topic><topic>Immune Tolerance - drug effects</topic><topic>IMMUNOLOGICAL DEFICIENCY</topic><topic>immunosuppression</topic><topic>intoxication</topic><topic>LEAD</topic><topic>Lead - blood</topic><topic>Lead - toxicity</topic><topic>Lead Poisoning - immunology</topic><topic>Lead Poisoning - veterinary</topic><topic>Lymphocyte Activation - drug effects</topic><topic>lymphocyte transformation</topic><topic>Male</topic><topic>mallard</topic><topic>Marine</topic><topic>PATO</topic><topic>PLOMB</topic><topic>PLOMO</topic><topic>Random Allocation</topic><topic>REPONSE IMMUNITAIRE</topic><topic>RESPUESTA INMUNOLOGICA</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Trust, Kimberly A.</creatorcontrib><creatorcontrib>Miller, Michael W.</creatorcontrib><creatorcontrib>Ringelman, James K.</creatorcontrib><creatorcontrib>Orme, Ian M.</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 1: Biological Sciences & Living Resources</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 3: Aquatic Pollution & Environmental Quality</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Aquaculture Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><jtitle>Journal of wildlife diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Trust, Kimberly A.</au><au>Miller, Michael W.</au><au>Ringelman, James K.</au><au>Orme, Ian M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>EFFECTS OF INGESTED LEAD ON ANTIBODY PRODUCTION IN MALLARDS (ANAS PLATYRHYNCHOS)</atitle><jtitle>Journal of wildlife diseases</jtitle><addtitle>J Wildl Dis</addtitle><date>1990-07-01</date><risdate>1990</risdate><volume>26</volume><issue>3</issue><spage>316</spage><epage>322</epage><pages>316-322</pages><issn>0090-3558</issn><eissn>1943-3700</eissn><abstract>We examined the effects of lead ingestion on in vitro and in vivo indices of immune function in mallards (Anas platyrhynchos). Twenty-four mallard drakes were randomly divided into three groups (I, II, III), then assigned to treatment or control subgroups (n = 4). On day 0, all treatment birds were dosed orally with one number 4 lead shot (x̄ = 0.2 g). We challenged all individuals in each group with washed sheep red blood cells (SRBC) injected intraperitoneally on days 0 (Group I), 7 (Group II) or 14 (Group III), and collected blood for analyses 7 and 8 days after SRBC challenge. We measured and compared blood lead concentrations, in vitro lymphocyte transformation responses to phytohemagglutinin A and lipopolysaccharide, and hemagglutination titers to SRBC. Mean blood lead concentrations were elevated (P ≤ 0.04) in treatment birds at each sampling period. Large individual variability in lymphocyte stimulation responses precluded further analysis of those data. Hemagglutination titers to SRBC were lower (P < 0.0001) in lead-poisoned ducks than in controls, suggesting that ingested lead may have immunosuppressive effects on mallards.</abstract><cop>United States</cop><pub>Wildlife Disease Association</pub><pmid>2388354</pmid><doi>10.7589/0090-3558-26.3.316</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0090-3558 |
| ispartof | Journal of wildlife diseases, 1990-07, Vol.26 (3), p.316-322 |
| issn | 0090-3558 1943-3700 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_15763402 |
| source | MEDLINE; BioOne Open Access Titles; Allen Press Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Anas platyrhynchos Animals Antibody Formation - drug effects Bird Diseases - immunology Body Weight - drug effects Brackish CANARD DEFICIENCE IMMUNOLOGIQUE DEFICIENCIA INMUNOLOGICA DUCKS Ducks - immunology experimental study Freshwater hemagglutination Hemagglutination - drug effects IMMUNE RESPONSE Immune Tolerance - drug effects IMMUNOLOGICAL DEFICIENCY immunosuppression intoxication LEAD Lead - blood Lead - toxicity Lead Poisoning - immunology Lead Poisoning - veterinary Lymphocyte Activation - drug effects lymphocyte transformation Male mallard Marine PATO PLOMB PLOMO Random Allocation REPONSE IMMUNITAIRE RESPUESTA INMUNOLOGICA |
| title | EFFECTS OF INGESTED LEAD ON ANTIBODY PRODUCTION IN MALLARDS (ANAS PLATYRHYNCHOS) |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-01T19%3A50%3A25IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=EFFECTS%20OF%20INGESTED%20LEAD%20ON%20ANTIBODY%20PRODUCTION%20IN%20MALLARDS%20(ANAS%20PLATYRHYNCHOS)&rft.jtitle=Journal%20of%20wildlife%20diseases&rft.au=Trust,%20Kimberly%20A.&rft.date=1990-07-01&rft.volume=26&rft.issue=3&rft.spage=316&rft.epage=322&rft.pages=316-322&rft.issn=0090-3558&rft.eissn=1943-3700&rft_id=info:doi/10.7589/0090-3558-26.3.316&rft_dat=%3Cproquest_cross%3E15763402%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=15763402&rft_id=info:pmid/2388354&rfr_iscdi=true |