Pituitary adenylate cyclase-activating polypeptide protects rat-cultured cortical neurons from glutamate-induced cytotoxicity

We have investigated the effects of pituitary adenylate cyclase-activating polypeptide with 38 residues (PACAP38) on glutamate-induced neuronal cell death in rat-cultured cortical neurons. The rat-cultured neurons were obtained from E17 day-old embryos and cultured in a chemically defined medium wit...

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Veröffentlicht in:	Brain research 1996-11, Vol.741 (1), p.82-88
Hauptverfasser:	Morio, Hiroshi, Tatsuno, Ichiro, Hirai, Aizan, Tamura, Yasushi, Saito, Yasushi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arginine Vasopressin - pharmacology Bucladesine - pharmacology Cell Survival - drug effects Cells, Cultured Cerebral Cortex - cytology Cerebral Cortex - drug effects Cortical neuron Cyclic AMP Cyclic AMP - metabolism Cytoprotection Glutamate Glutamic Acid - toxicity Natriuretic Peptide, Brain Nerve Tissue Proteins - pharmacology Neurons - drug effects Neuropeptides - pharmacology Neuroprotective Agents - pharmacology Neurotoxicity PACAP Pituitary Adenylate Cyclase-Activating Polypeptide Rats Rats, Sprague-Dawley Signal Transduction - drug effects
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