Erythropoietin has a Mitogenic and Positive Chemotactic Effect on Endothelial Cells
Erythropoietin is known to be a hematopoietic growth factor with a singularly specific action on the proliferation and differentiation of erythroid progenitor cells. We have observed a dose-dependent proliferative action of human recombinant erythropoietin on human umbilical vein endothelial cells a...
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| Veröffentlicht in: | Proceedings of the National Academy of Sciences - PNAS 1990-08, Vol.87 (15), p.5978-5982 |
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| creator | Anagnostou, Athanasius Lee, Eun Sun Kessimian, Noubar Levinson, Rachel Steiner, Manfred |
| description | Erythropoietin is known to be a hematopoietic growth factor with a singularly specific action on the proliferation and differentiation of erythroid progenitor cells. We have observed a dose-dependent proliferative action of human recombinant erythropoietin on human umbilical vein endothelial cells and bovine adrenal capillary endothelial cells. Binding studies with radioiodinated recombinant human erythropoietin revealed a large number (≈27,000) of an apparent single class of receptors with an affinity in the 10-9M range. Linkage of the radiolabeled ligand to its receptor via a bifunctional crosslinking agent allowed us to identify an endothelial cell protein of 45 kDa as the principal receptor associated with this mitogenic effect of erythropoietin. Recombinant human erythropoietin also enhanced the migration of endothelial cells. |
| doi_str_mv | 10.1073/pnas.87.15.5978 |
| format | Article |
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We have observed a dose-dependent proliferative action of human recombinant erythropoietin on human umbilical vein endothelial cells and bovine adrenal capillary endothelial cells. Binding studies with radioiodinated recombinant human erythropoietin revealed a large number (≈27,000) of an apparent single class of receptors with an affinity in the 10-9M range. Linkage of the radiolabeled ligand to its receptor via a bifunctional crosslinking agent allowed us to identify an endothelial cell protein of 45 kDa as the principal receptor associated with this mitogenic effect of erythropoietin. Recombinant human erythropoietin also enhanced the migration of endothelial cells.</description><identifier>ISSN: 0027-8424</identifier><identifier>EISSN: 1091-6490</identifier><identifier>DOI: 10.1073/pnas.87.15.5978</identifier><identifier>PMID: 2165612</identifier><identifier>CODEN: PNASA6</identifier><language>eng</language><publisher>Washington, DC: National Academy of Sciences of the United States of America</publisher><subject>550201 - Biochemistry- Tracer Techniques ; ANIMAL TISSUES ; BASIC BIOLOGICAL SCIENCES ; BETA DECAY RADIOISOTOPES ; Biological and medical sciences ; BIOLOGICAL EFFECTS ; BODY ; Cell differentiation, maturation, development, hematopoiesis ; Cell Division - drug effects ; Cell growth ; Cell lines ; Cell physiology ; CELL PROLIFERATION ; Cells, Cultured ; Cellular receptors ; chemotaxis ; Chemotaxis - drug effects ; Cross-Linking Reagents - metabolism ; DAYS LIVING RADIOISOTOPES ; DNA Replication - drug effects ; ELECTRON CAPTURE RADIOISOTOPES ; Endothelial cells ; ENDOTHELIUM ; Endothelium, Vascular - cytology ; Endothelium, Vascular - drug effects ; Endothelium, Vascular - physiology ; Epics ; Erythroid cells ; ERYTHROPOIETIN ; Erythropoietin - metabolism ; Erythropoietin - pharmacology ; Female ; Fundamental and applied biological sciences. Psychology ; GROWTH FACTORS ; HEMATOPOIETIC SYSTEM ; Human umbilical vein endothelial cells ; Humans ; INTERMEDIATE MASS NUCLEI ; IODINE 125 ; IODINE ISOTOPES ; ISOTOPE APPLICATIONS ; ISOTOPES ; Kinetics ; Medical genetics ; MEMBRANE PROTEINS ; mitogenesis ; MITOGENS ; Molecular and cellular biology ; NUCLEI ; ODD-EVEN NUCLEI ; ORGANIC COMPOUNDS ; Pregnancy ; PROTEINS ; RADIOISOTOPES ; RADIORECEPTOR ASSAY ; RECEPTORS ; Receptors, Cell Surface - isolation & purification ; Receptors, Cell Surface - metabolism ; Receptors, Erythropoietin ; Recombinant Proteins - metabolism ; Recombinant Proteins - pharmacology ; Succinimides - metabolism ; TISSUES ; TRACER TECHNIQUES ; Ungulates</subject><ispartof>Proceedings of the National Academy of Sciences - PNAS, 1990-08, Vol.87 (15), p.5978-5982</ispartof><rights>1991 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c616t-c72c3338324ecb60346147b0e684ba7e4a3d587a7df823fc226ba66a2b8bbbe63</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://www.pnas.org/content/87/15.cover.gif</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/2355049$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/2355049$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,727,780,784,803,885,27924,27925,53791,53793,58017,58250</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19424000$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2165612$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://www.osti.gov/biblio/6214107$$D View this record in Osti.gov$$Hfree_for_read</backlink></links><search><creatorcontrib>Anagnostou, Athanasius</creatorcontrib><creatorcontrib>Lee, Eun Sun</creatorcontrib><creatorcontrib>Kessimian, Noubar</creatorcontrib><creatorcontrib>Levinson, Rachel</creatorcontrib><creatorcontrib>Steiner, Manfred</creatorcontrib><title>Erythropoietin has a Mitogenic and Positive Chemotactic Effect on Endothelial Cells</title><title>Proceedings of the National Academy of Sciences - PNAS</title><addtitle>Proc Natl Acad Sci U S A</addtitle><description>Erythropoietin is known to be a hematopoietic growth factor with a singularly specific action on the proliferation and differentiation of erythroid progenitor cells. We have observed a dose-dependent proliferative action of human recombinant erythropoietin on human umbilical vein endothelial cells and bovine adrenal capillary endothelial cells. Binding studies with radioiodinated recombinant human erythropoietin revealed a large number (≈27,000) of an apparent single class of receptors with an affinity in the 10-9M range. Linkage of the radiolabeled ligand to its receptor via a bifunctional crosslinking agent allowed us to identify an endothelial cell protein of 45 kDa as the principal receptor associated with this mitogenic effect of erythropoietin. Recombinant human erythropoietin also enhanced the migration of endothelial cells.</description><subject>550201 - Biochemistry- Tracer Techniques</subject><subject>ANIMAL TISSUES</subject><subject>BASIC BIOLOGICAL SCIENCES</subject><subject>BETA DECAY RADIOISOTOPES</subject><subject>Biological and medical sciences</subject><subject>BIOLOGICAL EFFECTS</subject><subject>BODY</subject><subject>Cell differentiation, maturation, development, hematopoiesis</subject><subject>Cell Division - drug effects</subject><subject>Cell growth</subject><subject>Cell lines</subject><subject>Cell physiology</subject><subject>CELL PROLIFERATION</subject><subject>Cells, Cultured</subject><subject>Cellular receptors</subject><subject>chemotaxis</subject><subject>Chemotaxis - drug effects</subject><subject>Cross-Linking Reagents - metabolism</subject><subject>DAYS LIVING RADIOISOTOPES</subject><subject>DNA Replication - drug effects</subject><subject>ELECTRON CAPTURE RADIOISOTOPES</subject><subject>Endothelial cells</subject><subject>ENDOTHELIUM</subject><subject>Endothelium, Vascular - cytology</subject><subject>Endothelium, Vascular - drug effects</subject><subject>Endothelium, Vascular - physiology</subject><subject>Epics</subject><subject>Erythroid cells</subject><subject>ERYTHROPOIETIN</subject><subject>Erythropoietin - metabolism</subject><subject>Erythropoietin - pharmacology</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>GROWTH FACTORS</subject><subject>HEMATOPOIETIC SYSTEM</subject><subject>Human umbilical vein endothelial cells</subject><subject>Humans</subject><subject>INTERMEDIATE MASS NUCLEI</subject><subject>IODINE 125</subject><subject>IODINE ISOTOPES</subject><subject>ISOTOPE APPLICATIONS</subject><subject>ISOTOPES</subject><subject>Kinetics</subject><subject>Medical genetics</subject><subject>MEMBRANE PROTEINS</subject><subject>mitogenesis</subject><subject>MITOGENS</subject><subject>Molecular and cellular biology</subject><subject>NUCLEI</subject><subject>ODD-EVEN NUCLEI</subject><subject>ORGANIC COMPOUNDS</subject><subject>Pregnancy</subject><subject>PROTEINS</subject><subject>RADIOISOTOPES</subject><subject>RADIORECEPTOR ASSAY</subject><subject>RECEPTORS</subject><subject>Receptors, Cell Surface - isolation & purification</subject><subject>Receptors, Cell Surface - metabolism</subject><subject>Receptors, Erythropoietin</subject><subject>Recombinant Proteins - metabolism</subject><subject>Recombinant Proteins - pharmacology</subject><subject>Succinimides - metabolism</subject><subject>TISSUES</subject><subject>TRACER TECHNIQUES</subject><subject>Ungulates</subject><issn>0027-8424</issn><issn>1091-6490</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFks1rFDEYxoNY6nb17EVlKKin2eY7GfBSltUKFQX1HDKZTCdlNlmTbGn_ezPs2NqLnnJ4fs_79QSAlwiuEBTkbOd1WkmxQmzFGiGfgAWCDao5beBTsIAQi1pSTJ-Bk5SuIYQNk_AYHGPEGUd4Ab5v4l0eYtgFZ7Pz1aBTpasvLocr652ptO-qbyG57G5stR7sNmRtchE2fW9NroKvNr4LebCj02O1tuOYnoOjXo_JvpjfJfj5cfNjfVFffv30eX1-WRuOeK6NwIYQIgmm1rQcEsoRFS20XNJWC0s16ZgUWnS9xKQ3GPNWc65xK9u2tZwswYdD3d2-3drOWJ-jHtUuuq2Odypopx4r3g3qKtwoRikjxX56sIeUnUrGZWsGE7wveymOEZ0OvATv5h4x_NrblNXWJVO21N6GfVKiaRCkuPkviJgoB0e4gGcH0MSQUrT9_cAIqqmlmjJVUhSLmjItjtd_73nPzyEW_e2s62T02EftjUsPZZvyAUr0hXszc1ODP_KjRu__Cah-P47Z3uZCvjqQ1ymH-DARYQzShvwGzJ3MXg</recordid><startdate>19900801</startdate><enddate>19900801</enddate><creator>Anagnostou, Athanasius</creator><creator>Lee, Eun Sun</creator><creator>Kessimian, Noubar</creator><creator>Levinson, Rachel</creator><creator>Steiner, Manfred</creator><general>National Academy of Sciences of the United States of America</general><general>National Acad Sciences</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QR</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>M81</scope><scope>P64</scope><scope>7X8</scope><scope>OTOTI</scope><scope>5PM</scope></search><sort><creationdate>19900801</creationdate><title>Erythropoietin has a Mitogenic and Positive Chemotactic Effect on Endothelial Cells</title><author>Anagnostou, Athanasius ; Lee, Eun Sun ; Kessimian, Noubar ; Levinson, Rachel ; Steiner, Manfred</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c616t-c72c3338324ecb60346147b0e684ba7e4a3d587a7df823fc226ba66a2b8bbbe63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>550201 - Biochemistry- Tracer Techniques</topic><topic>ANIMAL TISSUES</topic><topic>BASIC BIOLOGICAL SCIENCES</topic><topic>BETA DECAY RADIOISOTOPES</topic><topic>Biological and medical sciences</topic><topic>BIOLOGICAL EFFECTS</topic><topic>BODY</topic><topic>Cell differentiation, maturation, development, hematopoiesis</topic><topic>Cell Division - drug effects</topic><topic>Cell growth</topic><topic>Cell lines</topic><topic>Cell physiology</topic><topic>CELL PROLIFERATION</topic><topic>Cells, Cultured</topic><topic>Cellular receptors</topic><topic>chemotaxis</topic><topic>Chemotaxis - drug effects</topic><topic>Cross-Linking Reagents - metabolism</topic><topic>DAYS LIVING RADIOISOTOPES</topic><topic>DNA Replication - drug effects</topic><topic>ELECTRON CAPTURE RADIOISOTOPES</topic><topic>Endothelial cells</topic><topic>ENDOTHELIUM</topic><topic>Endothelium, Vascular - cytology</topic><topic>Endothelium, Vascular - drug effects</topic><topic>Endothelium, Vascular - physiology</topic><topic>Epics</topic><topic>Erythroid cells</topic><topic>ERYTHROPOIETIN</topic><topic>Erythropoietin - metabolism</topic><topic>Erythropoietin - pharmacology</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>GROWTH FACTORS</topic><topic>HEMATOPOIETIC SYSTEM</topic><topic>Human umbilical vein endothelial cells</topic><topic>Humans</topic><topic>INTERMEDIATE MASS NUCLEI</topic><topic>IODINE 125</topic><topic>IODINE ISOTOPES</topic><topic>ISOTOPE APPLICATIONS</topic><topic>ISOTOPES</topic><topic>Kinetics</topic><topic>Medical genetics</topic><topic>MEMBRANE PROTEINS</topic><topic>mitogenesis</topic><topic>MITOGENS</topic><topic>Molecular and cellular biology</topic><topic>NUCLEI</topic><topic>ODD-EVEN NUCLEI</topic><topic>ORGANIC COMPOUNDS</topic><topic>Pregnancy</topic><topic>PROTEINS</topic><topic>RADIOISOTOPES</topic><topic>RADIORECEPTOR ASSAY</topic><topic>RECEPTORS</topic><topic>Receptors, Cell Surface - isolation & purification</topic><topic>Receptors, Cell Surface - metabolism</topic><topic>Receptors, Erythropoietin</topic><topic>Recombinant Proteins - metabolism</topic><topic>Recombinant Proteins - pharmacology</topic><topic>Succinimides - metabolism</topic><topic>TISSUES</topic><topic>TRACER TECHNIQUES</topic><topic>Ungulates</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Anagnostou, Athanasius</creatorcontrib><creatorcontrib>Lee, Eun Sun</creatorcontrib><creatorcontrib>Kessimian, Noubar</creatorcontrib><creatorcontrib>Levinson, Rachel</creatorcontrib><creatorcontrib>Steiner, Manfred</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Chemoreception Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biochemistry Abstracts 3</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><collection>OSTI.GOV</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Proceedings of the National Academy of Sciences - PNAS</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Anagnostou, Athanasius</au><au>Lee, Eun Sun</au><au>Kessimian, Noubar</au><au>Levinson, Rachel</au><au>Steiner, Manfred</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Erythropoietin has a Mitogenic and Positive Chemotactic Effect on Endothelial Cells</atitle><jtitle>Proceedings of the National Academy of Sciences - PNAS</jtitle><addtitle>Proc Natl Acad Sci U S A</addtitle><date>1990-08-01</date><risdate>1990</risdate><volume>87</volume><issue>15</issue><spage>5978</spage><epage>5982</epage><pages>5978-5982</pages><issn>0027-8424</issn><eissn>1091-6490</eissn><coden>PNASA6</coden><abstract>Erythropoietin is known to be a hematopoietic growth factor with a singularly specific action on the proliferation and differentiation of erythroid progenitor cells. We have observed a dose-dependent proliferative action of human recombinant erythropoietin on human umbilical vein endothelial cells and bovine adrenal capillary endothelial cells. Binding studies with radioiodinated recombinant human erythropoietin revealed a large number (≈27,000) of an apparent single class of receptors with an affinity in the 10-9M range. Linkage of the radiolabeled ligand to its receptor via a bifunctional crosslinking agent allowed us to identify an endothelial cell protein of 45 kDa as the principal receptor associated with this mitogenic effect of erythropoietin. Recombinant human erythropoietin also enhanced the migration of endothelial cells.</abstract><cop>Washington, DC</cop><pub>National Academy of Sciences of the United States of America</pub><pmid>2165612</pmid><doi>10.1073/pnas.87.15.5978</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Proceedings of the National Academy of Sciences - PNAS, 1990-08, Vol.87 (15), p.5978-5982 |
| issn | 0027-8424 1091-6490 |
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| subjects | 550201 - Biochemistry- Tracer Techniques ANIMAL TISSUES BASIC BIOLOGICAL SCIENCES BETA DECAY RADIOISOTOPES Biological and medical sciences BIOLOGICAL EFFECTS BODY Cell differentiation, maturation, development, hematopoiesis Cell Division - drug effects Cell growth Cell lines Cell physiology CELL PROLIFERATION Cells, Cultured Cellular receptors chemotaxis Chemotaxis - drug effects Cross-Linking Reagents - metabolism DAYS LIVING RADIOISOTOPES DNA Replication - drug effects ELECTRON CAPTURE RADIOISOTOPES Endothelial cells ENDOTHELIUM Endothelium, Vascular - cytology Endothelium, Vascular - drug effects Endothelium, Vascular - physiology Epics Erythroid cells ERYTHROPOIETIN Erythropoietin - metabolism Erythropoietin - pharmacology Female Fundamental and applied biological sciences. Psychology GROWTH FACTORS HEMATOPOIETIC SYSTEM Human umbilical vein endothelial cells Humans INTERMEDIATE MASS NUCLEI IODINE 125 IODINE ISOTOPES ISOTOPE APPLICATIONS ISOTOPES Kinetics Medical genetics MEMBRANE PROTEINS mitogenesis MITOGENS Molecular and cellular biology NUCLEI ODD-EVEN NUCLEI ORGANIC COMPOUNDS Pregnancy PROTEINS RADIOISOTOPES RADIORECEPTOR ASSAY RECEPTORS Receptors, Cell Surface - isolation & purification Receptors, Cell Surface - metabolism Receptors, Erythropoietin Recombinant Proteins - metabolism Recombinant Proteins - pharmacology Succinimides - metabolism TISSUES TRACER TECHNIQUES Ungulates |
| title | Erythropoietin has a Mitogenic and Positive Chemotactic Effect on Endothelial Cells |
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