Overexpression of lecithin:cholesterol acyltransferase in transgenic rabbits prevents diet-induced atherosclerosis

Lecithin:cholesterol acyltransferase (LCAT) is a key plasma enzyme in cholesterol and high density lipoprotein (HDL) metabolism. Transgenic rabbits overexpressing human LCAT had 15-fold greater plasma LCAT activity than nontransgenic control rabbits. This degree of overexpression was associated with...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1996-10, Vol.93 (21), p.11448-11453
Hauptverfasser:	Hoeg, J.M. (National Institutes of Health, Bethesda, MD.), Santamarina-Fojo, S, Berard, A.M, Cornhill, J.F, Herderick, E.E, Feldmand, S.H, Haudenschild, C.C, Vaisman, B.L, Hoyt, R.F. Jr, Demosky, S.J. Jr
Format:	Artikel
Sprache:	eng
Schlagworte:	ACILTRANSFERASA ACTIVIDAD ENZIMATICA ACTIVITE ENZYMATIQUE ACYLTRANSFERASE ANIMAL TRANSGENIQUE ANIMALES TRANSGENICOS Animals Animals, Genetically Modified Aorta Aorta, Thoracic - pathology ARTERIOSCLEROSE ARTERIOSCLEROSIS Arteriosclerosis - blood Arteriosclerosis - pathology Arteriosclerosis - prevention & control Atherosclerosis Biology Blood plasma Cardiovascular disease CHOLESTEROL Cholesterol - blood Cholesterol, HDL - blood Cholesterols COLESTEROL CONEJO (ORYCTOLAGUS) Diet, Atherogenic ESTER ESTERES EXPERIMENTACION EXPERIMENTATION EXPRESION GENICA EXPRESSION DES GENES GENE GENES Genetic Therapy HDL lipoproteins HEMOLIPIDOS Humans LAPIN (ORYCTOLAGUS) LIPIDE SANGUIN Lipids LIPOPROTEINAS LIPOPROTEINE Lipoproteins Lipoproteins - blood Phosphatidylcholine-Sterol O-Acyltransferase - biosynthesis Phosphatidylcholine-Sterol O-Acyltransferase - blood Phosphatidylcholine-Sterol O-Acyltransferase - genetics Rabbits Reference Values Regression Analysis Transgenic animals Transgenic plants TRIGLICERIDOS TRIGLYCERIDE Triglycerides - blood Tunica Intima - pathology
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