Developmental toxicity of concanavalin a in rats: Association with restricted migration of neural crest cells

Concanavalin A (Con A), a plant lectin, was injected iv into pregnant rats as a single dose of 5, 10 or 20 mg/kg on gestational day (GD) 8, to investigate developmental toxicity in foetuses at term and to examine histologically embryos between GD 10 and 12. There were high incidences of various malf...

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Veröffentlicht in:	Food and chemical toxicology 1996-08, Vol.34 (8), p.701-708
Hauptverfasser:	Nishida, A., Kobayashi, T., Ariyuki, F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Abnormalities, Drug-Induced Analysis of Variance Animals Biological and medical sciences Body Weight - drug effects Bone and Bones - abnormalities Bone and Bones - drug effects Brain - drug effects Brain - pathology Cell Movement - drug effects Concanavalin A - toxicity Craniofacial Abnormalities - chemically induced Embryology: invertebrates and vertebrates. Teratology Embryonic and Fetal Development - drug effects Female Fundamental and applied biological sciences. Psychology Gestational Age Heart Defects, Congenital - chemically induced Male Neural Crest - cytology Neural Crest - drug effects Pregnancy Rats Rats, Sprague-Dawley Teratology. Teratogens
Online-Zugang:	Volltext
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