Comparison of the effects of acute and subacute treatment of phenobarbital in different strains of mice

A strain specificity has been demonstrated for the effect of subsequent administration of phenobarbital (PB), in which diethylnitrosamine (DENA)-initiated hepatocarcinogenesis was promoted in C3H mice, inhibited in B6C3F1 (C57BL × C3H) and not affected in C57BL mice. A correlation has been establish...

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Veröffentlicht in:	Cancer letters 1989-11, Vol.48 (1), p.43-51
Hauptverfasser:	Lin, E.L.C., Klaunig, J.E., Mattox, J.K., Weghorst, C.M., McFarland, B.H., Pereira, M.A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aminopyrine N-Demethylase - metabolism Animals Biological and medical sciences Carcinogenesis, carcinogens and anticarcinogens Chemical agents cytochrome P-450 Cytochrome P-450 CYP1A1 Cytochrome P-450 Enzyme System - metabolism DNA - metabolism DNA synthesis Dose-Response Relationship, Drug Liver - anatomy & histology Liver Neoplasms, Experimental - chemically induced Liver Neoplasms, Experimental - genetics Medical sciences Mice Mice, Inbred Strains - physiology Microsomes, Liver - metabolism mixed function oxidases Organ Size - drug effects Oxidoreductases - metabolism phenobarbital Phenobarbital - administration & dosage Testosterone - metabolism Time Factors Tumors
Online-Zugang:	Volltext
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