Effects of ofloxacin on cell-mediated immune response and lymphokine production
The effects of orally administered ofloxacin on functional parameters of cell-mediated immunity were investigated in 15 patients with respiratory or urinary tract infections. Mononuclear leucocytes were obtained before administering the drug, 1 h after the first dose, and five days later. The cells...
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| Veröffentlicht in: | Journal of antimicrobial chemotherapy 1990-05, Vol.25 (5), p.797-802 |
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| container_issue | 5 |
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| container_title | Journal of antimicrobial chemotherapy |
| container_volume | 25 |
| creator | Biglino, Alberto Forno, Brunella Pollono, Anna M. Basso, Margherita Arpinelli, Francesco Benedetto, Marco Pugliese, Agostino |
| description | The effects of orally administered ofloxacin on functional parameters of cell-mediated immunity were investigated in 15 patients with respiratory or urinary tract infections. Mononuclear leucocytes were obtained before administering the drug, 1 h after the first dose, and five days later. The cells were stimulated with lectins, tetanus toxoid and Newcastle Disease virus in order to assess mitogen- and antigen-induced lymphocyte proliferation and production of γ-interferon, interleulrin-2 and α-interferon. An increase in proliferative response to pokeweed mitogen and a slight but significant decrease in α-interferon production were observed, while other parameters remained unaffected by treatment. |
| doi_str_mv | 10.1093/jac/25.5.797 |
| format | Article |
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Mononuclear leucocytes were obtained before administering the drug, 1 h after the first dose, and five days later. The cells were stimulated with lectins, tetanus toxoid and Newcastle Disease virus in order to assess mitogen- and antigen-induced lymphocyte proliferation and production of γ-interferon, interleulrin-2 and α-interferon. 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Mononuclear leucocytes were obtained before administering the drug, 1 h after the first dose, and five days later. The cells were stimulated with lectins, tetanus toxoid and Newcastle Disease virus in order to assess mitogen- and antigen-induced lymphocyte proliferation and production of γ-interferon, interleulrin-2 and α-interferon. An increase in proliferative response to pokeweed mitogen and a slight but significant decrease in α-interferon production were observed, while other parameters remained unaffected by treatment.</description><subject>Analysis of Variance</subject><subject>Humans</subject><subject>Immunity, Cellular - drug effects</subject><subject>Interferon Type I - biosynthesis</subject><subject>Interferon-gamma - biosynthesis</subject><subject>Interleukin-2 - biosynthesis</subject><subject>Lectins - pharmacology</subject><subject>Lymphocyte Activation - immunology</subject><subject>Lymphokines - biosynthesis</subject><subject>Newcastle disease virus - immunology</subject><subject>Ofloxacin - adverse effects</subject><subject>Ofloxacin - therapeutic use</subject><subject>Respiratory Tract Infections - drug therapy</subject><subject>Respiratory Tract Infections - immunology</subject><subject>Tetanus Toxoid - pharmacology</subject><subject>Urinary Tract Infections - drug therapy</subject><subject>Urinary Tract Infections - immunology</subject><issn>0305-7453</issn><issn>1460-2091</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kMtLxDAQxoMouj5uXoWePNndpOkk6VEWX7Ao4gPxErLJFOu2TW1a2P3vjewiDAzM9-ObmY-Qc0anjBZ89m3sLIMpTGUh98iE5YKmGS3YPplQTiGVOfAjchzCN6VUgFCH5DBjDICxCXm6KUu0Q0h8Gav2a2OrNvFtYrGu0wZdZQZ0SdU0Y4tJj6HzbcDEtC6pN0335VdVnHe9d6MdKt-ekoPS1AHPdv2EvN3evM7v08XT3cP8epFaDjCkVrgcFKN5DpkCi8hVDs44KIUUqqBmCSjQUeEsK0zkFCylRIWMF1QqxU_I5dY3rv4ZMQy6qcLfzaZFPwbNQEImcxrBqy1oex9Cj6Xu-qox_UYzqv_y0zE_nYEGHfOL-MXOd1zG7__hXWBRT7d6FQZc_8umX2khuQR9__Gp75h8fHnmXL_zX8VAeoI</recordid><startdate>19900501</startdate><enddate>19900501</enddate><creator>Biglino, Alberto</creator><creator>Forno, Brunella</creator><creator>Pollono, Anna M.</creator><creator>Basso, Margherita</creator><creator>Arpinelli, Francesco</creator><creator>Benedetto, Marco</creator><creator>Pugliese, Agostino</creator><general>Oxford University Press</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope></search><sort><creationdate>19900501</creationdate><title>Effects of ofloxacin on cell-mediated immune response and lymphokine production</title><author>Biglino, Alberto ; Forno, Brunella ; Pollono, Anna M. ; Basso, Margherita ; Arpinelli, Francesco ; Benedetto, Marco ; Pugliese, Agostino</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c355t-c6d45810445285cee3845dad5f676890ab5e6ed06dc19a10485b77e8e13907883</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Analysis of Variance</topic><topic>Humans</topic><topic>Immunity, Cellular - drug effects</topic><topic>Interferon Type I - biosynthesis</topic><topic>Interferon-gamma - biosynthesis</topic><topic>Interleukin-2 - biosynthesis</topic><topic>Lectins - pharmacology</topic><topic>Lymphocyte Activation - immunology</topic><topic>Lymphokines - biosynthesis</topic><topic>Newcastle disease virus - immunology</topic><topic>Ofloxacin - adverse effects</topic><topic>Ofloxacin - therapeutic use</topic><topic>Respiratory Tract Infections - drug therapy</topic><topic>Respiratory Tract Infections - immunology</topic><topic>Tetanus Toxoid - pharmacology</topic><topic>Urinary Tract Infections - drug therapy</topic><topic>Urinary Tract Infections - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Biglino, Alberto</creatorcontrib><creatorcontrib>Forno, Brunella</creatorcontrib><creatorcontrib>Pollono, Anna M.</creatorcontrib><creatorcontrib>Basso, Margherita</creatorcontrib><creatorcontrib>Arpinelli, Francesco</creatorcontrib><creatorcontrib>Benedetto, Marco</creatorcontrib><creatorcontrib>Pugliese, Agostino</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Journal of antimicrobial chemotherapy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Biglino, Alberto</au><au>Forno, Brunella</au><au>Pollono, Anna M.</au><au>Basso, Margherita</au><au>Arpinelli, Francesco</au><au>Benedetto, Marco</au><au>Pugliese, Agostino</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of ofloxacin on cell-mediated immune response and lymphokine production</atitle><jtitle>Journal of antimicrobial chemotherapy</jtitle><addtitle>J Antimicrob Chemother</addtitle><date>1990-05-01</date><risdate>1990</risdate><volume>25</volume><issue>5</issue><spage>797</spage><epage>802</epage><pages>797-802</pages><issn>0305-7453</issn><eissn>1460-2091</eissn><abstract>The effects of orally administered ofloxacin on functional parameters of cell-mediated immunity were investigated in 15 patients with respiratory or urinary tract infections. Mononuclear leucocytes were obtained before administering the drug, 1 h after the first dose, and five days later. The cells were stimulated with lectins, tetanus toxoid and Newcastle Disease virus in order to assess mitogen- and antigen-induced lymphocyte proliferation and production of γ-interferon, interleulrin-2 and α-interferon. An increase in proliferative response to pokeweed mitogen and a slight but significant decrease in α-interferon production were observed, while other parameters remained unaffected by treatment.</abstract><cop>England</cop><pub>Oxford University Press</pub><pmid>2115511</pmid><doi>10.1093/jac/25.5.797</doi><tpages>6</tpages></addata></record> |
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| ispartof | Journal of antimicrobial chemotherapy, 1990-05, Vol.25 (5), p.797-802 |
| issn | 0305-7453 1460-2091 |
| language | eng |
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| source | MEDLINE; Oxford University Press Journals Digital Archive Legacy |
| subjects | Analysis of Variance Humans Immunity, Cellular - drug effects Interferon Type I - biosynthesis Interferon-gamma - biosynthesis Interleukin-2 - biosynthesis Lectins - pharmacology Lymphocyte Activation - immunology Lymphokines - biosynthesis Newcastle disease virus - immunology Ofloxacin - adverse effects Ofloxacin - therapeutic use Respiratory Tract Infections - drug therapy Respiratory Tract Infections - immunology Tetanus Toxoid - pharmacology Urinary Tract Infections - drug therapy Urinary Tract Infections - immunology |
| title | Effects of ofloxacin on cell-mediated immune response and lymphokine production |
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