Surface modification can affect the carcinogenicity of asbestos
A sample of amosite asbestos was modified by effectively adding C8 and C18 hydrocarbon chains to the fibre surfaces. The altered fibres interacted less readily with cells in vitro and were less cytotoxic. In whole animals the number of mesotheliomas produced by the C8 material was the same as that w...
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| Veröffentlicht in: | Carcinogenesis (New York) 1990-10, Vol.11 (10), p.1883-1885 |
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| container_end_page | 1885 |
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| container_issue | 10 |
| container_start_page | 1883 |
| container_title | Carcinogenesis (New York) |
| container_volume | 11 |
| creator | Brown, R.C. Carthew, P. Hoskins, J.A. Sara, E. Simpson, C.F. |
| description | A sample of amosite asbestos was modified by effectively adding C8 and C18 hydrocarbon chains to the fibre surfaces. The altered fibres interacted less readily with cells in vitro and were less cytotoxic. In whole animals the number of mesotheliomas produced by the C8 material was the same as that with the parent material but the tumours occurred earlier. The C18 derivatized fibre was markedly less active in the production of tumours. This is the first report demonstrating that similar size fibres with differing surfaces have different pathogenic properties. |
| doi_str_mv | 10.1093/carcin/11.10.1883 |
| format | Article |
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The altered fibres interacted less readily with cells in vitro and were less cytotoxic. In whole animals the number of mesotheliomas produced by the C8 material was the same as that with the parent material but the tumours occurred earlier. The C18 derivatized fibre was markedly less active in the production of tumours. This is the first report demonstrating that similar size fibres with differing surfaces have different pathogenic properties.</description><identifier>ISSN: 0143-3334</identifier><identifier>EISSN: 1460-2180</identifier><identifier>DOI: 10.1093/carcin/11.10.1883</identifier><identifier>PMID: 2170048</identifier><identifier>CODEN: CRNGDP</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>Animals ; Asbestos - chemistry ; Asbestos - pharmacology ; Asbestos - toxicity ; Asbestos, Amosite ; Biological and medical sciences ; Carcinogenesis, carcinogens and anticarcinogens ; Carcinogenicity Tests ; Carcinogens - toxicity ; Cell Line ; Cell Survival - drug effects ; Chemical agents ; Medical sciences ; Mesothelioma - chemically induced ; Mesothelioma - pathology ; Rats ; Reference Values ; Surface Properties ; Tumors</subject><ispartof>Carcinogenesis (New York), 1990-10, Vol.11 (10), p.1883-1885</ispartof><rights>1991 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c395t-5b32fab4f773c4418b40d6e9fe913e604eec1547a1c490138c802d41177310753</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27922,27923</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19414251$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2170048$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Brown, R.C.</creatorcontrib><creatorcontrib>Carthew, P.</creatorcontrib><creatorcontrib>Hoskins, J.A.</creatorcontrib><creatorcontrib>Sara, E.</creatorcontrib><creatorcontrib>Simpson, C.F.</creatorcontrib><title>Surface modification can affect the carcinogenicity of asbestos</title><title>Carcinogenesis (New York)</title><addtitle>Carcinogenesis</addtitle><description>A sample of amosite asbestos was modified by effectively adding C8 and C18 hydrocarbon chains to the fibre surfaces. The altered fibres interacted less readily with cells in vitro and were less cytotoxic. In whole animals the number of mesotheliomas produced by the C8 material was the same as that with the parent material but the tumours occurred earlier. The C18 derivatized fibre was markedly less active in the production of tumours. This is the first report demonstrating that similar size fibres with differing surfaces have different pathogenic properties.</description><subject>Animals</subject><subject>Asbestos - chemistry</subject><subject>Asbestos - pharmacology</subject><subject>Asbestos - toxicity</subject><subject>Asbestos, Amosite</subject><subject>Biological and medical sciences</subject><subject>Carcinogenesis, carcinogens and anticarcinogens</subject><subject>Carcinogenicity Tests</subject><subject>Carcinogens - toxicity</subject><subject>Cell Line</subject><subject>Cell Survival - drug effects</subject><subject>Chemical agents</subject><subject>Medical sciences</subject><subject>Mesothelioma - chemically induced</subject><subject>Mesothelioma - pathology</subject><subject>Rats</subject><subject>Reference Values</subject><subject>Surface Properties</subject><subject>Tumors</subject><issn>0143-3334</issn><issn>1460-2180</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkE9LAzEQxYMotVY_gAdhL3rbNrOT7G5OokWtICioIL2EbJpodP_UZAv227t1Sz0NvPebN8wj5BToGKjAiVZeu3oCMN4oeY57ZAgspXECOd0nQwoMY0Rkh-QohE9KIUUuBmSQQEYpy4fk8nnlrdImqpqFs06r1jV1pFUdKWuNbqP2w0T9mebd1E67dh01NlKhMKFtwjE5sKoM5mQ7R-T19uZlOosfHu_up1cPsUbB25gXmFhVMJtlqBmDvGB0kRphjQA0KWXGaOAsU6CZoIC5zmmyYAAdDzTjOCIXfe7SN9-r7rSsXNCmLFVtmlWQwDOepKnoQOhB7ZsQvLFy6V2l_FoClZvSZP-NBPhTutK6nbNt-KqozGK3sW2p88-3vgpaldarWrvwHywYsIRDx8U950Jrfna-8l8yzTDjcvY2l09znAmcXcsUfwEoPIPl</recordid><startdate>19901001</startdate><enddate>19901001</enddate><creator>Brown, R.C.</creator><creator>Carthew, P.</creator><creator>Hoskins, J.A.</creator><creator>Sara, E.</creator><creator>Simpson, C.F.</creator><general>Oxford University Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>19901001</creationdate><title>Surface modification can affect the carcinogenicity of asbestos</title><author>Brown, R.C. ; Carthew, P. ; Hoskins, J.A. ; Sara, E. ; Simpson, C.F.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c395t-5b32fab4f773c4418b40d6e9fe913e604eec1547a1c490138c802d41177310753</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Animals</topic><topic>Asbestos - chemistry</topic><topic>Asbestos - pharmacology</topic><topic>Asbestos - toxicity</topic><topic>Asbestos, Amosite</topic><topic>Biological and medical sciences</topic><topic>Carcinogenesis, carcinogens and anticarcinogens</topic><topic>Carcinogenicity Tests</topic><topic>Carcinogens - toxicity</topic><topic>Cell Line</topic><topic>Cell Survival - drug effects</topic><topic>Chemical agents</topic><topic>Medical sciences</topic><topic>Mesothelioma - chemically induced</topic><topic>Mesothelioma - pathology</topic><topic>Rats</topic><topic>Reference Values</topic><topic>Surface Properties</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Brown, R.C.</creatorcontrib><creatorcontrib>Carthew, P.</creatorcontrib><creatorcontrib>Hoskins, J.A.</creatorcontrib><creatorcontrib>Sara, E.</creatorcontrib><creatorcontrib>Simpson, C.F.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Carcinogenesis (New York)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Brown, R.C.</au><au>Carthew, P.</au><au>Hoskins, J.A.</au><au>Sara, E.</au><au>Simpson, C.F.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Surface modification can affect the carcinogenicity of asbestos</atitle><jtitle>Carcinogenesis (New York)</jtitle><addtitle>Carcinogenesis</addtitle><date>1990-10-01</date><risdate>1990</risdate><volume>11</volume><issue>10</issue><spage>1883</spage><epage>1885</epage><pages>1883-1885</pages><issn>0143-3334</issn><eissn>1460-2180</eissn><coden>CRNGDP</coden><abstract>A sample of amosite asbestos was modified by effectively adding C8 and C18 hydrocarbon chains to the fibre surfaces. 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| fulltext | fulltext |
| identifier | ISSN: 0143-3334 |
| ispartof | Carcinogenesis (New York), 1990-10, Vol.11 (10), p.1883-1885 |
| issn | 0143-3334 1460-2180 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_15752669 |
| source | MEDLINE; Oxford University Press Journals Digital Archive Legacy |
| subjects | Animals Asbestos - chemistry Asbestos - pharmacology Asbestos - toxicity Asbestos, Amosite Biological and medical sciences Carcinogenesis, carcinogens and anticarcinogens Carcinogenicity Tests Carcinogens - toxicity Cell Line Cell Survival - drug effects Chemical agents Medical sciences Mesothelioma - chemically induced Mesothelioma - pathology Rats Reference Values Surface Properties Tumors |
| title | Surface modification can affect the carcinogenicity of asbestos |
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