Sparging and agitation-induced injury of cultured animal cells: do cell-to-bubble interactions in the bulk liquid injure cells?

It has been established that the forces resulting from bubbles rupturing at the free air (gas)/liquid surface injure animal cells in agitated and/or sparged bioreactors. Although it has been suggested that bubble coalescence and breakup within agitated and sparged bioreactors (i.e., away from the fr...

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Veröffentlicht in:	Biotechnology and bioengineering 1996-08, Vol.51 (4), p.399-409
Hauptverfasser:	Michaels, J.D. (Systemix Inc., Palo Alto, CA.), Mallik, A.K, Papoutsakis, E.T
Format:	Artikel
Sprache:	eng
Schlagworte:	ANIMAL ANIMALES CELLULE CELULAS
Online-Zugang:	Volltext
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