In vivo measurements of nasal airway dimensions and ultrafine aerosol deposition in the human nasal and oral airways
Understanding the filtration efficiency of the nasal and oral airways is essential for assessing doses of inhaled particles to the extrathoracic region as well as to the lung. This paper presents in vivo measurements of nasal airway dimensions and the extrathoracic deposition of ultrafine aerosols i...
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| Veröffentlicht in: | Journal of aerosol science 1996-07, Vol.27 (5), p.785-801 |
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| container_title | Journal of aerosol science |
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| creator | Cheng, Kuo-Hsi Cheng, Yung-Sung Yeh, Hsu-Chi Guilmette, Raymond A. Simpson, Steven Q. Yang, Yi-Hsin Swift, David L. |
| description | Understanding the filtration efficiency of the nasal and oral airways is essential for assessing doses of inhaled particles to the extrathoracic region as well as to the lung. This paper presents
in vivo measurements of nasal airway dimensions and the extrathoracic deposition of ultrafine aerosols in 10 normal adult males. The nasal geometry of each subject was characterized using magnetic resonance imaging and acoustic rhinometry. The nasal and oral deposition efficiencies were measured for particles ranging from 4 to 150 run at constant flow rates of 167 and 333 cm
3s
−1. Results indicated that both nasal dimensions and particle deposition varied significantly among individuals. Inter-individual variability in particle deposition was correlated with the wide inter-individual variation of nasal dimensions measured by the total surface area, minimum cross-sectional area, and complexity of the airway shape. We concluded that the significant biological variability in extrathoracic filtration of ultrafine aerosols must be considered in developing population-wide dosimetry of inhaled particles. |
| doi_str_mv | 10.1016/0021-8502(96)00029-8 |
| format | Article |
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in vivo measurements of nasal airway dimensions and the extrathoracic deposition of ultrafine aerosols in 10 normal adult males. The nasal geometry of each subject was characterized using magnetic resonance imaging and acoustic rhinometry. The nasal and oral deposition efficiencies were measured for particles ranging from 4 to 150 run at constant flow rates of 167 and 333 cm
3s
−1. Results indicated that both nasal dimensions and particle deposition varied significantly among individuals. Inter-individual variability in particle deposition was correlated with the wide inter-individual variation of nasal dimensions measured by the total surface area, minimum cross-sectional area, and complexity of the airway shape. We concluded that the significant biological variability in extrathoracic filtration of ultrafine aerosols must be considered in developing population-wide dosimetry of inhaled particles.</description><identifier>ISSN: 0021-8502</identifier><identifier>EISSN: 1879-1964</identifier><identifier>DOI: 10.1016/0021-8502(96)00029-8</identifier><identifier>CODEN: JALSB7</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Air breathing ; Biological and medical sciences ; Fundamental and applied biological sciences. Psychology ; Respiratory system: anatomy, metabolism, gas exchange, ventilatory mechanics, respiratory hemodynamics ; Vertebrates: respiratory system</subject><ispartof>Journal of aerosol science, 1996-07, Vol.27 (5), p.785-801</ispartof><rights>1996</rights><rights>1996 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c476t-f3cdd376dadc599fec79d309e7adaed78f9f72e76e6d60f14684f1607bf9407f3</citedby><cites>FETCH-LOGICAL-c476t-f3cdd376dadc599fec79d309e7adaed78f9f72e76e6d60f14684f1607bf9407f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0021-8502(96)00029-8$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>309,310,314,777,781,786,787,3537,23911,23912,25121,27905,27906,45976</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3141360$$DView record in Pascal Francis$$Hfree_for_read</backlink></links><search><creatorcontrib>Cheng, Kuo-Hsi</creatorcontrib><creatorcontrib>Cheng, Yung-Sung</creatorcontrib><creatorcontrib>Yeh, Hsu-Chi</creatorcontrib><creatorcontrib>Guilmette, Raymond A.</creatorcontrib><creatorcontrib>Simpson, Steven Q.</creatorcontrib><creatorcontrib>Yang, Yi-Hsin</creatorcontrib><creatorcontrib>Swift, David L.</creatorcontrib><title>In vivo measurements of nasal airway dimensions and ultrafine aerosol deposition in the human nasal and oral airways</title><title>Journal of aerosol science</title><description>Understanding the filtration efficiency of the nasal and oral airways is essential for assessing doses of inhaled particles to the extrathoracic region as well as to the lung. This paper presents
in vivo measurements of nasal airway dimensions and the extrathoracic deposition of ultrafine aerosols in 10 normal adult males. The nasal geometry of each subject was characterized using magnetic resonance imaging and acoustic rhinometry. The nasal and oral deposition efficiencies were measured for particles ranging from 4 to 150 run at constant flow rates of 167 and 333 cm
3s
−1. Results indicated that both nasal dimensions and particle deposition varied significantly among individuals. Inter-individual variability in particle deposition was correlated with the wide inter-individual variation of nasal dimensions measured by the total surface area, minimum cross-sectional area, and complexity of the airway shape. We concluded that the significant biological variability in extrathoracic filtration of ultrafine aerosols must be considered in developing population-wide dosimetry of inhaled particles.</description><subject>Air breathing</subject><subject>Biological and medical sciences</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Respiratory system: anatomy, metabolism, gas exchange, ventilatory mechanics, respiratory hemodynamics</subject><subject>Vertebrates: respiratory system</subject><issn>0021-8502</issn><issn>1879-1964</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><recordid>eNp9kE9rGzEQxUVpoa7bb9CDDqE0h00l71paXQrB5B8EeknOYiqNiMqu5Gh2HfztI-PEx56GGX7vDe8x9l2KCymk-iXESjb9Wqx-GnUu6maa_gNbyF6bRhrVfWSLE_KZfSH6VyFt5HrBprvEd3GX-YhAc8ER00Q8B56AYOAQywvsuY_1TjEn4pA8n4epQIgJOWDJlAfucZspTpXgMfHpCfnTPEJ6d6maXE529JV9CjAQfnubS_Z4ffWwuW3u_9zcbS7vG9dpNTWhdd63Wnnwbm1MQKeNb4VBDR7Q6z6YoFeoFSqvRJCd6rsgldB_g-mEDu2S_Tj6bkt-npEmO0ZyOAyQMM9k5Vp3Qq1MBbsj6GocKhjstsQRyt5KYQ8V20N_9tCfNYelVmz7Kjt78wdyMIQCyUU6aVvZyVaJiv0-Yliz7iIWSy5icuhjQTdZn-P__7wCoj6SFw</recordid><startdate>19960701</startdate><enddate>19960701</enddate><creator>Cheng, Kuo-Hsi</creator><creator>Cheng, Yung-Sung</creator><creator>Yeh, Hsu-Chi</creator><creator>Guilmette, Raymond A.</creator><creator>Simpson, Steven Q.</creator><creator>Yang, Yi-Hsin</creator><creator>Swift, David L.</creator><general>Elsevier Ltd</general><general>Elsevier Science</general><scope>IQODW</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope></search><sort><creationdate>19960701</creationdate><title>In vivo measurements of nasal airway dimensions and ultrafine aerosol deposition in the human nasal and oral airways</title><author>Cheng, Kuo-Hsi ; Cheng, Yung-Sung ; Yeh, Hsu-Chi ; Guilmette, Raymond A. ; Simpson, Steven Q. ; Yang, Yi-Hsin ; Swift, David L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c476t-f3cdd376dadc599fec79d309e7adaed78f9f72e76e6d60f14684f1607bf9407f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Air breathing</topic><topic>Biological and medical sciences</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Respiratory system: anatomy, metabolism, gas exchange, ventilatory mechanics, respiratory hemodynamics</topic><topic>Vertebrates: respiratory system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cheng, Kuo-Hsi</creatorcontrib><creatorcontrib>Cheng, Yung-Sung</creatorcontrib><creatorcontrib>Yeh, Hsu-Chi</creatorcontrib><creatorcontrib>Guilmette, Raymond A.</creatorcontrib><creatorcontrib>Simpson, Steven Q.</creatorcontrib><creatorcontrib>Yang, Yi-Hsin</creatorcontrib><creatorcontrib>Swift, David L.</creatorcontrib><collection>Pascal-Francis</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Journal of aerosol science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cheng, Kuo-Hsi</au><au>Cheng, Yung-Sung</au><au>Yeh, Hsu-Chi</au><au>Guilmette, Raymond A.</au><au>Simpson, Steven Q.</au><au>Yang, Yi-Hsin</au><au>Swift, David L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>In vivo measurements of nasal airway dimensions and ultrafine aerosol deposition in the human nasal and oral airways</atitle><jtitle>Journal of aerosol science</jtitle><date>1996-07-01</date><risdate>1996</risdate><volume>27</volume><issue>5</issue><spage>785</spage><epage>801</epage><pages>785-801</pages><issn>0021-8502</issn><eissn>1879-1964</eissn><coden>JALSB7</coden><abstract>Understanding the filtration efficiency of the nasal and oral airways is essential for assessing doses of inhaled particles to the extrathoracic region as well as to the lung. This paper presents
in vivo measurements of nasal airway dimensions and the extrathoracic deposition of ultrafine aerosols in 10 normal adult males. The nasal geometry of each subject was characterized using magnetic resonance imaging and acoustic rhinometry. The nasal and oral deposition efficiencies were measured for particles ranging from 4 to 150 run at constant flow rates of 167 and 333 cm
3s
−1. Results indicated that both nasal dimensions and particle deposition varied significantly among individuals. Inter-individual variability in particle deposition was correlated with the wide inter-individual variation of nasal dimensions measured by the total surface area, minimum cross-sectional area, and complexity of the airway shape. We concluded that the significant biological variability in extrathoracic filtration of ultrafine aerosols must be considered in developing population-wide dosimetry of inhaled particles.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><doi>10.1016/0021-8502(96)00029-8</doi><tpages>17</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0021-8502 |
| ispartof | Journal of aerosol science, 1996-07, Vol.27 (5), p.785-801 |
| issn | 0021-8502 1879-1964 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_15740629 |
| source | Elsevier ScienceDirect Journals |
| subjects | Air breathing Biological and medical sciences Fundamental and applied biological sciences. Psychology Respiratory system: anatomy, metabolism, gas exchange, ventilatory mechanics, respiratory hemodynamics Vertebrates: respiratory system |
| title | In vivo measurements of nasal airway dimensions and ultrafine aerosol deposition in the human nasal and oral airways |
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