Isolation and structure of the cytostatic depsipeptide dolastatin 13 from the sea hare Dolabella auricularia

The Indian Ocean shell-less mollusc Dolabella auricularia superficially appears to lack predator defenses. Such seemingly defenseless animals are only attacked by certain carnivorous members of this gastropod subclass. Evidence is now accumulating that Opisthobranchia species have developed very pow...

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Veröffentlicht in:Journal of the American Chemical Society 1989, Vol.111 (13), p.5015-5017
Hauptverfasser: PETTIT, G. R, KAMANO, Y, HERALD, C. L, DUFRESNE, C, CERNY, R. L, HERALD, D. L, SCHMIDT, J. M, KIZU, H
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container_end_page 5017
container_issue 13
container_start_page 5015
container_title Journal of the American Chemical Society
container_volume 111
creator PETTIT, G. R
KAMANO, Y
HERALD, C. L
DUFRESNE, C
CERNY, R. L
HERALD, D. L
SCHMIDT, J. M
KIZU, H
description The Indian Ocean shell-less mollusc Dolabella auricularia superficially appears to lack predator defenses. Such seemingly defenseless animals are only attacked by certain carnivorous members of this gastropod subclass. Evidence is now accumulating that Opisthobranchia species have developed very powerful chemical defenses by careful selection and/or biosynthetic manipulation of various dietary sources such as blue-green algae and sponges.
doi_str_mv 10.1021/ja00195a084
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source ACS Publications
subjects Analytical, structural and metabolic biochemistry
Biological and medical sciences
Carbohydrates
Dolabella auricularia
Fundamental and applied biological sciences. Psychology
Marine
Other biological molecules
title Isolation and structure of the cytostatic depsipeptide dolastatin 13 from the sea hare Dolabella auricularia
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