Induction of myelin-associated glycoprotein mRNA in experimental remyelination
Two forms of myelin-associated glycoprotein (MAG) mRNA are produced by alternative splicing of the exon 12 portion. Expression of the two forms of MAG mRNA was studied here in experimentally introduced demyelination and remyelination by Cuprizone intoxication. During the demyelinating stage, both fo...
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| Veröffentlicht in: | Brain research 1990-04, Vol.513 (1), p.152-155 |
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| container_title | Brain research |
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| creator | Fujita, Nobuya Ishiguro, Hideaki Sato, Shuzo Kurihara, Tadashi Kuwano, Ryozo Sakimura, Kenji Takahashi, Yasuo Miyatake, Tadashi |
| description | Two forms of myelin-associated glycoprotein (MAG) mRNA are produced by alternative splicing of the exon 12 portion. Expression of the two forms of MAG mRNA was studied here in experimentally introduced demyelination and remyelination by Cuprizone intoxication. During the demyelinating stage, both forms of MAG mRNA decreased markedly. When feeding with Cuprizone was stopped, MAG mRNA began to increase. One form of MAG mRNA without the exon 12 portion, which appears in normal development at the period of active myelination, was characteristically induced during the remyelinating stage. The other form containing the exon 12 portion was also induced but recovered only to the level in normal development. |
| doi_str_mv | 10.1016/0006-8993(90)91102-M |
| format | Article |
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Expression of the two forms of MAG mRNA was studied here in experimentally introduced demyelination and remyelination by Cuprizone intoxication. During the demyelinating stage, both forms of MAG mRNA decreased markedly. When feeding with Cuprizone was stopped, MAG mRNA began to increase. One form of MAG mRNA without the exon 12 portion, which appears in normal development at the period of active myelination, was characteristically induced during the remyelinating stage. The other form containing the exon 12 portion was also induced but recovered only to the level in normal development.</description><identifier>ISSN: 0006-8993</identifier><identifier>EISSN: 1872-6240</identifier><identifier>DOI: 10.1016/0006-8993(90)91102-M</identifier><identifier>PMID: 1693539</identifier><identifier>CODEN: BRREAP</identifier><language>eng</language><publisher>London: Elsevier B.V</publisher><subject>2′,3′-Cyclic-nucleotide 3′-phosphodiesterase ; Alternative splicing ; Animals ; Biological and medical sciences ; Brain - metabolism ; Brain - physiology ; Cuprizone ; Cuprizone - toxicity ; Cyclohexanes - toxicity ; Fundamental and applied biological sciences. Psychology ; Gene Expression Regulation ; Male ; Mice ; Molecular and cellular biology ; Molecular genetics ; Myelin Proteins - genetics ; Myelin Proteins - metabolism ; Myelin Sheath - drug effects ; Myelin Sheath - physiology ; Myelin-Associated Glycoprotein ; Remyelination ; RNA, Messenger - genetics ; RNA, Messenger - metabolism ; Transcription. Transcription factor. Splicing. 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Expression of the two forms of MAG mRNA was studied here in experimentally introduced demyelination and remyelination by Cuprizone intoxication. During the demyelinating stage, both forms of MAG mRNA decreased markedly. When feeding with Cuprizone was stopped, MAG mRNA began to increase. One form of MAG mRNA without the exon 12 portion, which appears in normal development at the period of active myelination, was characteristically induced during the remyelinating stage. The other form containing the exon 12 portion was also induced but recovered only to the level in normal development.</description><subject>2′,3′-Cyclic-nucleotide 3′-phosphodiesterase</subject><subject>Alternative splicing</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Brain - metabolism</subject><subject>Brain - physiology</subject><subject>Cuprizone</subject><subject>Cuprizone - toxicity</subject><subject>Cyclohexanes - toxicity</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene Expression Regulation</subject><subject>Male</subject><subject>Mice</subject><subject>Molecular and cellular biology</subject><subject>Molecular genetics</subject><subject>Myelin Proteins - genetics</subject><subject>Myelin Proteins - metabolism</subject><subject>Myelin Sheath - drug effects</subject><subject>Myelin Sheath - physiology</subject><subject>Myelin-Associated Glycoprotein</subject><subject>Remyelination</subject><subject>RNA, Messenger - genetics</subject><subject>RNA, Messenger - metabolism</subject><subject>Transcription. Transcription factor. Splicing. Rna processing</subject><issn>0006-8993</issn><issn>1872-6240</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kF9LwzAUxYMoc06_gUIfRPShmjRt2rwIY_hnsE0QfQ5peiuRNplJJ-7bm9qhbz5dwv2dk3MPQqcEXxNM2A3GmMUF5_SS4ytOCE7i5R4akyJPYpakeB-Nf5FDdOT9e3hSyvEIjQjjNKN8jFZzU21Up62JbB21W2i0iaX3VmnZQRW9NVtl1852oE3UPq-mUZjwtQanWzCdbCIHg0r2JsfooJaNh5PdnKDX-7uX2WO8eHqYz6aLWFFedDEpElbWZZVKCgnFTOYpA4ozUpcJZzItaQAoydOMs4JkrMqqPPCMACgJqqQTdDH4hmgfG_CdaLVX0DTSgN14QbKcFlk4d4LSAVTOeu-gFuuQXLqtIFj0NYq-I9F3JDgWPzWKZZCd7fw3ZQvVn2joLezPd3vplWxqJ43S_hcLVEJY__vtgEHo4lODE15pMAoq7UB1orL6_xzfEN6O5w</recordid><startdate>19900409</startdate><enddate>19900409</enddate><creator>Fujita, Nobuya</creator><creator>Ishiguro, Hideaki</creator><creator>Sato, Shuzo</creator><creator>Kurihara, Tadashi</creator><creator>Kuwano, Ryozo</creator><creator>Sakimura, Kenji</creator><creator>Takahashi, Yasuo</creator><creator>Miyatake, Tadashi</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope></search><sort><creationdate>19900409</creationdate><title>Induction of myelin-associated glycoprotein mRNA in experimental remyelination</title><author>Fujita, Nobuya ; Ishiguro, Hideaki ; Sato, Shuzo ; Kurihara, Tadashi ; Kuwano, Ryozo ; Sakimura, Kenji ; Takahashi, Yasuo ; Miyatake, Tadashi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c398t-1826bfbd4a3e2306a746e3051fb296a4b382631745968156d5d7bfb61eecaecb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>2′,3′-Cyclic-nucleotide 3′-phosphodiesterase</topic><topic>Alternative splicing</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Brain - metabolism</topic><topic>Brain - physiology</topic><topic>Cuprizone</topic><topic>Cuprizone - toxicity</topic><topic>Cyclohexanes - toxicity</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gene Expression Regulation</topic><topic>Male</topic><topic>Mice</topic><topic>Molecular and cellular biology</topic><topic>Molecular genetics</topic><topic>Myelin Proteins - genetics</topic><topic>Myelin Proteins - metabolism</topic><topic>Myelin Sheath - drug effects</topic><topic>Myelin Sheath - physiology</topic><topic>Myelin-Associated Glycoprotein</topic><topic>Remyelination</topic><topic>RNA, Messenger - genetics</topic><topic>RNA, Messenger - metabolism</topic><topic>Transcription. Transcription factor. Splicing. Rna processing</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fujita, Nobuya</creatorcontrib><creatorcontrib>Ishiguro, Hideaki</creatorcontrib><creatorcontrib>Sato, Shuzo</creatorcontrib><creatorcontrib>Kurihara, Tadashi</creatorcontrib><creatorcontrib>Kuwano, Ryozo</creatorcontrib><creatorcontrib>Sakimura, Kenji</creatorcontrib><creatorcontrib>Takahashi, Yasuo</creatorcontrib><creatorcontrib>Miyatake, Tadashi</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><jtitle>Brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fujita, Nobuya</au><au>Ishiguro, Hideaki</au><au>Sato, Shuzo</au><au>Kurihara, Tadashi</au><au>Kuwano, Ryozo</au><au>Sakimura, Kenji</au><au>Takahashi, Yasuo</au><au>Miyatake, Tadashi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Induction of myelin-associated glycoprotein mRNA in experimental remyelination</atitle><jtitle>Brain research</jtitle><addtitle>Brain Res</addtitle><date>1990-04-09</date><risdate>1990</risdate><volume>513</volume><issue>1</issue><spage>152</spage><epage>155</epage><pages>152-155</pages><issn>0006-8993</issn><eissn>1872-6240</eissn><coden>BRREAP</coden><abstract>Two forms of myelin-associated glycoprotein (MAG) mRNA are produced by alternative splicing of the exon 12 portion. Expression of the two forms of MAG mRNA was studied here in experimentally introduced demyelination and remyelination by Cuprizone intoxication. During the demyelinating stage, both forms of MAG mRNA decreased markedly. When feeding with Cuprizone was stopped, MAG mRNA began to increase. One form of MAG mRNA without the exon 12 portion, which appears in normal development at the period of active myelination, was characteristically induced during the remyelinating stage. The other form containing the exon 12 portion was also induced but recovered only to the level in normal development.</abstract><cop>London</cop><cop>Amsterdam</cop><cop>New York, NY</cop><pub>Elsevier B.V</pub><pmid>1693539</pmid><doi>10.1016/0006-8993(90)91102-M</doi><tpages>4</tpages></addata></record> |
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| subjects | 2′,3′-Cyclic-nucleotide 3′-phosphodiesterase Alternative splicing Animals Biological and medical sciences Brain - metabolism Brain - physiology Cuprizone Cuprizone - toxicity Cyclohexanes - toxicity Fundamental and applied biological sciences. Psychology Gene Expression Regulation Male Mice Molecular and cellular biology Molecular genetics Myelin Proteins - genetics Myelin Proteins - metabolism Myelin Sheath - drug effects Myelin Sheath - physiology Myelin-Associated Glycoprotein Remyelination RNA, Messenger - genetics RNA, Messenger - metabolism Transcription. Transcription factor. Splicing. Rna processing |
| title | Induction of myelin-associated glycoprotein mRNA in experimental remyelination |
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