Histidine decarboxylase in human basophilic leukemia (KU-812-F) cells: Characterization and induction by phorbol myristate acetate

The human leukemic cell line KU-812-F is known to differentiate into mature basophil-like cells under serum-free culture conditions. In the present study, the activity of histidine decarboxylase (HDC), a histamine-forming enzyme, in KU-812-F cells was found to be high, ranging from 10 to 57 pmol/min...

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Veröffentlicht in:	Biochemical pharmacology 1990-09, Vol.40 (5), p.1125-1129
Hauptverfasser:	Ruriko, Mamune-Sato, Yasuo, Tanno, Kazutaka, Maeyama, Yasuko, Miura, Tamotsu, Takishima, Kenji, Kishi, Takeaki, Fukuda, Takehiko, Watanabe
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkaloids - pharmacology basophilic leukemia Biological and medical sciences Calcimycin - pharmacology Carboxy-Lyases - metabolism Carcinogenesis, carcinogens and anticarcinogens Chemical agents Cycloheximide - pharmacology Enzyme Induction - drug effects Histidine Decarboxylase - metabolism Humans Leukemia, Basophilic, Acute - enzymology Leukemia, Basophilic, Acute - metabolism Medical sciences phorbol 12-myristate 13-acetate diester Protein Kinase C - antagonists & inhibitors Staurosporine Tetradecanoylphorbol Acetate - pharmacology Tumor Cells, Cultured - drug effects Tumors
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