Histidine decarboxylase in human basophilic leukemia (KU-812-F) cells: Characterization and induction by phorbol myristate acetate
The human leukemic cell line KU-812-F is known to differentiate into mature basophil-like cells under serum-free culture conditions. In the present study, the activity of histidine decarboxylase (HDC), a histamine-forming enzyme, in KU-812-F cells was found to be high, ranging from 10 to 57 pmol/min...
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| Veröffentlicht in: | Biochemical pharmacology 1990-09, Vol.40 (5), p.1125-1129 |
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| creator | Ruriko, Mamune-Sato Yasuo, Tanno Kazutaka, Maeyama Yasuko, Miura Tamotsu, Takishima Kenji, Kishi Takeaki, Fukuda Takehiko, Watanabe |
| description | The human leukemic cell line KU-812-F is known to differentiate into mature basophil-like cells under serum-free culture conditions. In the present study, the activity of histidine decarboxylase (HDC), a histamine-forming enzyme, in KU-812-F cells was found to be high, ranging from 10 to 57 pmol/min/mg protein. The great variation in HDC activity appeared to be due to different percentages and degrees of maturity of basophil-like cells during differentiation of this cell line. The enzyme was inhibited by α-fluoromethylhistidine but not by carbidopa, was unable to form dopamine from
l-3, 4-dihydroxyphenylalanine, and had a
K
m
value for histidine of 0.27 mM, indicating that it was HDC and not aromatic amino acid decarboxylase. The HDC activity increased 1.8-fold when the cells were stimulated by phorbol myristate acetate, which is known to activate protein kinase C, and this increase was blocked by staurosporine, a potent inhibitor of protein kinase C. |
| doi_str_mv | 10.1016/0006-2952(90)90502-C |
| format | Article |
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l-3, 4-dihydroxyphenylalanine, and had a
K
m
value for histidine of 0.27 mM, indicating that it was HDC and not aromatic amino acid decarboxylase. The HDC activity increased 1.8-fold when the cells were stimulated by phorbol myristate acetate, which is known to activate protein kinase C, and this increase was blocked by staurosporine, a potent inhibitor of protein kinase C.</description><identifier>ISSN: 0006-2952</identifier><identifier>EISSN: 1873-2968</identifier><identifier>DOI: 10.1016/0006-2952(90)90502-C</identifier><identifier>PMID: 2117926</identifier><identifier>CODEN: BCPCA6</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Alkaloids - pharmacology ; basophilic leukemia ; Biological and medical sciences ; Calcimycin - pharmacology ; Carboxy-Lyases - metabolism ; Carcinogenesis, carcinogens and anticarcinogens ; Chemical agents ; Cycloheximide - pharmacology ; Enzyme Induction - drug effects ; Histidine Decarboxylase - metabolism ; Humans ; Leukemia, Basophilic, Acute - enzymology ; Leukemia, Basophilic, Acute - metabolism ; Medical sciences ; phorbol 12-myristate 13-acetate diester ; Protein Kinase C - antagonists & inhibitors ; Staurosporine ; Tetradecanoylphorbol Acetate - pharmacology ; Tumor Cells, Cultured - drug effects ; Tumors</subject><ispartof>Biochemical pharmacology, 1990-09, Vol.40 (5), p.1125-1129</ispartof><rights>1990</rights><rights>1991 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0006-2952(90)90502-C$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19431660$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2117926$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ruriko, Mamune-Sato</creatorcontrib><creatorcontrib>Yasuo, Tanno</creatorcontrib><creatorcontrib>Kazutaka, Maeyama</creatorcontrib><creatorcontrib>Yasuko, Miura</creatorcontrib><creatorcontrib>Tamotsu, Takishima</creatorcontrib><creatorcontrib>Kenji, Kishi</creatorcontrib><creatorcontrib>Takeaki, Fukuda</creatorcontrib><creatorcontrib>Takehiko, Watanabe</creatorcontrib><title>Histidine decarboxylase in human basophilic leukemia (KU-812-F) cells: Characterization and induction by phorbol myristate acetate</title><title>Biochemical pharmacology</title><addtitle>Biochem Pharmacol</addtitle><description>The human leukemic cell line KU-812-F is known to differentiate into mature basophil-like cells under serum-free culture conditions. In the present study, the activity of histidine decarboxylase (HDC), a histamine-forming enzyme, in KU-812-F cells was found to be high, ranging from 10 to 57 pmol/min/mg protein. The great variation in HDC activity appeared to be due to different percentages and degrees of maturity of basophil-like cells during differentiation of this cell line. The enzyme was inhibited by α-fluoromethylhistidine but not by carbidopa, was unable to form dopamine from
l-3, 4-dihydroxyphenylalanine, and had a
K
m
value for histidine of 0.27 mM, indicating that it was HDC and not aromatic amino acid decarboxylase. The HDC activity increased 1.8-fold when the cells were stimulated by phorbol myristate acetate, which is known to activate protein kinase C, and this increase was blocked by staurosporine, a potent inhibitor of protein kinase C.</description><subject>Alkaloids - pharmacology</subject><subject>basophilic leukemia</subject><subject>Biological and medical sciences</subject><subject>Calcimycin - pharmacology</subject><subject>Carboxy-Lyases - metabolism</subject><subject>Carcinogenesis, carcinogens and anticarcinogens</subject><subject>Chemical agents</subject><subject>Cycloheximide - pharmacology</subject><subject>Enzyme Induction - drug effects</subject><subject>Histidine Decarboxylase - metabolism</subject><subject>Humans</subject><subject>Leukemia, Basophilic, Acute - enzymology</subject><subject>Leukemia, Basophilic, Acute - metabolism</subject><subject>Medical sciences</subject><subject>phorbol 12-myristate 13-acetate diester</subject><subject>Protein Kinase C - antagonists & inhibitors</subject><subject>Staurosporine</subject><subject>Tetradecanoylphorbol Acetate - pharmacology</subject><subject>Tumor Cells, Cultured - drug effects</subject><subject>Tumors</subject><issn>0006-2952</issn><issn>1873-2968</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kU1v1DAQhi1EVZaFfwCSL1TtIeCxE8fmgIQiSisqcaFna-JMtIZ8LHZSdTn2l5O0q55GM_PonY-XsXcgPoIA_UkIoTNpC3luxYUVhZBZ9YJtwJRqKWvzkm2ekVfsdUq_19RoOGWnEqC0Um_Yw1VIU2jCQLwhj7Ee7w8dJuJh4Lu5x4HXmMb9LnTB847mP9QH5Oc_bjMDMru84J66Ln3m1Q4j-oli-IdTGAeOQ7NoNLN_zOoD3-_GRb3j_SEuI3Eijp7W-IadtNglenuMW3Z7-e1XdZXd_Px-XX29yUhJOWUWlRFGtHVeCrJCq7ZQaCC3baERsCnRlqZQhoxGXy_fAGFzqclCC4glqS07e9Ldx_HvTGlyfUjr-jjQOCcHRSnzVXjL3h_Bue6pcfsYeowHd3za0v9w7GPy2LURBx_SMwY2V6C1WLgvTxwtV90Fii75QIOnJkTyk2vG4EC41Uy3WuNWp5wV7tFMV6n_bYOQJA</recordid><startdate>19900901</startdate><enddate>19900901</enddate><creator>Ruriko, Mamune-Sato</creator><creator>Yasuo, Tanno</creator><creator>Kazutaka, Maeyama</creator><creator>Yasuko, Miura</creator><creator>Tamotsu, Takishima</creator><creator>Kenji, Kishi</creator><creator>Takeaki, Fukuda</creator><creator>Takehiko, Watanabe</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>8FD</scope><scope>FR3</scope><scope>M7Z</scope><scope>P64</scope></search><sort><creationdate>19900901</creationdate><title>Histidine decarboxylase in human basophilic leukemia (KU-812-F) cells: Characterization and induction by phorbol myristate acetate</title><author>Ruriko, Mamune-Sato ; Yasuo, Tanno ; Kazutaka, Maeyama ; Yasuko, Miura ; Tamotsu, Takishima ; Kenji, Kishi ; Takeaki, Fukuda ; Takehiko, Watanabe</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-e322t-9a38080fb470e9063f53a8149f56a1ad7a978538e86acb502109426e91f1aa7e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Alkaloids - pharmacology</topic><topic>basophilic leukemia</topic><topic>Biological and medical sciences</topic><topic>Calcimycin - pharmacology</topic><topic>Carboxy-Lyases - metabolism</topic><topic>Carcinogenesis, carcinogens and anticarcinogens</topic><topic>Chemical agents</topic><topic>Cycloheximide - pharmacology</topic><topic>Enzyme Induction - drug effects</topic><topic>Histidine Decarboxylase - metabolism</topic><topic>Humans</topic><topic>Leukemia, Basophilic, Acute - enzymology</topic><topic>Leukemia, Basophilic, Acute - metabolism</topic><topic>Medical sciences</topic><topic>phorbol 12-myristate 13-acetate diester</topic><topic>Protein Kinase C - antagonists & inhibitors</topic><topic>Staurosporine</topic><topic>Tetradecanoylphorbol Acetate - pharmacology</topic><topic>Tumor Cells, Cultured - drug effects</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ruriko, Mamune-Sato</creatorcontrib><creatorcontrib>Yasuo, Tanno</creatorcontrib><creatorcontrib>Kazutaka, Maeyama</creatorcontrib><creatorcontrib>Yasuko, Miura</creatorcontrib><creatorcontrib>Tamotsu, Takishima</creatorcontrib><creatorcontrib>Kenji, Kishi</creatorcontrib><creatorcontrib>Takeaki, Fukuda</creatorcontrib><creatorcontrib>Takehiko, Watanabe</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biochemistry Abstracts 1</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Biochemical pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ruriko, Mamune-Sato</au><au>Yasuo, Tanno</au><au>Kazutaka, Maeyama</au><au>Yasuko, Miura</au><au>Tamotsu, Takishima</au><au>Kenji, Kishi</au><au>Takeaki, Fukuda</au><au>Takehiko, Watanabe</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Histidine decarboxylase in human basophilic leukemia (KU-812-F) cells: Characterization and induction by phorbol myristate acetate</atitle><jtitle>Biochemical pharmacology</jtitle><addtitle>Biochem Pharmacol</addtitle><date>1990-09-01</date><risdate>1990</risdate><volume>40</volume><issue>5</issue><spage>1125</spage><epage>1129</epage><pages>1125-1129</pages><issn>0006-2952</issn><eissn>1873-2968</eissn><coden>BCPCA6</coden><abstract>The human leukemic cell line KU-812-F is known to differentiate into mature basophil-like cells under serum-free culture conditions. In the present study, the activity of histidine decarboxylase (HDC), a histamine-forming enzyme, in KU-812-F cells was found to be high, ranging from 10 to 57 pmol/min/mg protein. The great variation in HDC activity appeared to be due to different percentages and degrees of maturity of basophil-like cells during differentiation of this cell line. The enzyme was inhibited by α-fluoromethylhistidine but not by carbidopa, was unable to form dopamine from
l-3, 4-dihydroxyphenylalanine, and had a
K
m
value for histidine of 0.27 mM, indicating that it was HDC and not aromatic amino acid decarboxylase. The HDC activity increased 1.8-fold when the cells were stimulated by phorbol myristate acetate, which is known to activate protein kinase C, and this increase was blocked by staurosporine, a potent inhibitor of protein kinase C.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>2117926</pmid><doi>10.1016/0006-2952(90)90502-C</doi><tpages>5</tpages></addata></record> |
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| subjects | Alkaloids - pharmacology basophilic leukemia Biological and medical sciences Calcimycin - pharmacology Carboxy-Lyases - metabolism Carcinogenesis, carcinogens and anticarcinogens Chemical agents Cycloheximide - pharmacology Enzyme Induction - drug effects Histidine Decarboxylase - metabolism Humans Leukemia, Basophilic, Acute - enzymology Leukemia, Basophilic, Acute - metabolism Medical sciences phorbol 12-myristate 13-acetate diester Protein Kinase C - antagonists & inhibitors Staurosporine Tetradecanoylphorbol Acetate - pharmacology Tumor Cells, Cultured - drug effects Tumors |
| title | Histidine decarboxylase in human basophilic leukemia (KU-812-F) cells: Characterization and induction by phorbol myristate acetate |
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