An NMR self-diffusion study of the interactions between spermidine and oligonucleotides
Self‐diffusion coefficients have been determined by pulsed field gradient nmr methods for spermidine in solutions of the oligonucleotides d(GC)4 and d(GGAATTCC). The self‐diffusion behavior of spermidine in solution of d(GC)4 is very similar to that observed previously for methylspermidine (complete...
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| Veröffentlicht in: | Biopolymers 1996-04, Vol.38 (4), p.505-513 |
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| creator | Andreasson, Bo Nordenskiöld, Lars Braunlin, William H. |
| description | Self‐diffusion coefficients have been determined by pulsed field gradient nmr methods for spermidine in solutions of the oligonucleotides d(GC)4 and d(GGAATTCC). The self‐diffusion behavior of spermidine in solution of d(GC)4 is very similar to that observed previously for methylspermidine (completely N‐methylated spermidine). Moreover, the self‐diffusion behaviors of spermidine in solutions of d(GC)4 and d(GGAATTCC) are also quite similar, indicating that there is no significant influenceon on self‐diffusion of oligonucleotide base composition. Furthermore, self‐diffusion coefficients of the oligonucleotide d(GC)8 show only a small dependence on oligonucleotide concentration, and no measurable dependence on sodium ion or magnesium ion concentration. © 1996 John Wiley & Sons, Inc. |
| doi_str_mv | 10.1002/(SICI)1097-0282(199604)38:4<505::AID-BIP6>3.0.CO;2-X |
| format | Article |
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The self‐diffusion behavior of spermidine in solution of d(GC)4 is very similar to that observed previously for methylspermidine (completely N‐methylated spermidine). Moreover, the self‐diffusion behaviors of spermidine in solutions of d(GC)4 and d(GGAATTCC) are also quite similar, indicating that there is no significant influenceon on self‐diffusion of oligonucleotide base composition. 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Furthermore, self‐diffusion coefficients of the oligonucleotide d(GC)8 show only a small dependence on oligonucleotide concentration, and no measurable dependence on sodium ion or magnesium ion concentration. © 1996 John Wiley & Sons, Inc.</description><subject>Base Sequence</subject><subject>Diffusion</subject><subject>Drug Interactions</subject><subject>Magnetic Resonance Spectroscopy - methods</subject><subject>Molecular Sequence Data</subject><subject>Oligonucleotides - chemistry</subject><subject>Spermidine - chemistry</subject><issn>0006-3525</issn><issn>1097-0282</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkNFu0zAUhiMEGmXwCEi5QttFyrEd22mZkLrASqStRdvQdneU2ifgkSYlTjT69iS0KhcgcXVknd_ff_QFwRmDMQPgb09usjQ7ZTDREfCEn7DJREF8KpJpfCZBTqez7EN0nn1W78UYxunyHY_unwSjw4enwQgAVCQkl8-DF94_AMSxYHAUHCWJ0pzxUXA3q8LF1XXoqSwi64qi866uQt92dhvWRdh-o9BVLTW5afuFD1fUPhL1iQ01a2ddRWFe2bAu3de66kxJdess-ZfBsyIvPb3az-Pgy8XH2_RTdLmcZ-nsMjIijlXE4pwVEylYQdooQ4YYB2E519oUyvYnxrCaKGlWVkqS1jKdazKalImZ1CCOgzc77qapf3TkW1w7b6gs84rqzmMf4iKBIXi7C5qm9r6hAjeNW-fNFhng4Btx8I2DPhz04c43igRj7H0j9r5x8I0CAdMlcrzvsa_3_d1qTfYA3Qv-U_voStr-1fmfyn80_n732GiHdb6lnwds3nxHpYWWeLeYI5wv5tdXcIMX4hdLo6oq</recordid><startdate>199604</startdate><enddate>199604</enddate><creator>Andreasson, Bo</creator><creator>Nordenskiöld, Lars</creator><creator>Braunlin, William H.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope></search><sort><creationdate>199604</creationdate><title>An NMR self-diffusion study of the interactions between spermidine and oligonucleotides</title><author>Andreasson, Bo ; Nordenskiöld, Lars ; Braunlin, William H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3446-14a1f9531fe7c6cece1203d2277cf6d21240b965cbd55e5dd17a7ec7e6c415703</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Base Sequence</topic><topic>Diffusion</topic><topic>Drug Interactions</topic><topic>Magnetic Resonance Spectroscopy - methods</topic><topic>Molecular Sequence Data</topic><topic>Oligonucleotides - chemistry</topic><topic>Spermidine - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Andreasson, Bo</creatorcontrib><creatorcontrib>Nordenskiöld, Lars</creatorcontrib><creatorcontrib>Braunlin, William H.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Biopolymers</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Andreasson, Bo</au><au>Nordenskiöld, Lars</au><au>Braunlin, William H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>An NMR self-diffusion study of the interactions between spermidine and oligonucleotides</atitle><jtitle>Biopolymers</jtitle><addtitle>Biopolymers</addtitle><date>1996-04</date><risdate>1996</risdate><volume>38</volume><issue>4</issue><spage>505</spage><epage>513</epage><pages>505-513</pages><issn>0006-3525</issn><eissn>1097-0282</eissn><abstract>Self‐diffusion coefficients have been determined by pulsed field gradient nmr methods for spermidine in solutions of the oligonucleotides d(GC)4 and d(GGAATTCC). The self‐diffusion behavior of spermidine in solution of d(GC)4 is very similar to that observed previously for methylspermidine (completely N‐methylated spermidine). Moreover, the self‐diffusion behaviors of spermidine in solutions of d(GC)4 and d(GGAATTCC) are also quite similar, indicating that there is no significant influenceon on self‐diffusion of oligonucleotide base composition. Furthermore, self‐diffusion coefficients of the oligonucleotide d(GC)8 show only a small dependence on oligonucleotide concentration, and no measurable dependence on sodium ion or magnesium ion concentration. © 1996 John Wiley & Sons, Inc.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>8867212</pmid><doi>10.1002/(SICI)1097-0282(199604)38:4<505::AID-BIP6>3.0.CO;2-X</doi><tpages>9</tpages></addata></record> |
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| identifier | ISSN: 0006-3525 |
| ispartof | Biopolymers, 1996-04, Vol.38 (4), p.505-513 |
| issn | 0006-3525 1097-0282 |
| language | eng |
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| source | MEDLINE; Wiley Journals |
| subjects | Base Sequence Diffusion Drug Interactions Magnetic Resonance Spectroscopy - methods Molecular Sequence Data Oligonucleotides - chemistry Spermidine - chemistry |
| title | An NMR self-diffusion study of the interactions between spermidine and oligonucleotides |
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