Rapid appearance of hypomethylated DNA in livers of rats fed cancer-promoting, methyl-deficient diets

Prolonged intake of diets deficient in sources of methyl groups leads to development of hepatomas in rats and promotes chemical carcinogenesis in both rats and certain strains of mice. Since methylation of cytosine residues in regulatory regions can affect gene activity, several investigators have p...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 1989-08, Vol.49 (15), p.4094-4097
Hauptverfasser:	WAINFAN, E, DIZIK, M, STENDER, M, CHRISTMAN, J. K
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Carcinogenesis, carcinogens and anticarcinogens Chemical agents Choline Deficiency - metabolism DNA - metabolism Folic Acid Deficiency - metabolism Liver - metabolism Male Medical sciences Methionine - deficiency Methylation Neoplasms, Experimental - etiology Rats Rats, Inbred F344 RNA, Transfer - metabolism Tumors Vitamin B 12 Deficiency - metabolism
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