Taurine failed to protect against the embryotoxic effects of isotretinoin in the rat
Experimental evidence exists to indicate that retinoids may act as detergents to disrupt biological membranes. Taurine, an amino sulfonic acid, has been shown to possess membrane-stabilizing and cytoprotective properties. This study was undertaken to test whether taurine coadministered with isotreti...
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| Veröffentlicht in: | Fundamental and applied toxicology 1990-08, Vol.15 (2), p.249-257 |
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| creator | Agnish, Narsingh D. Rusin, Gregory DiNardo, Barbara |
| description | Experimental evidence exists to indicate that retinoids may act as detergents to disrupt biological membranes. Taurine, an amino sulfonic acid, has been shown to possess membrane-stabilizing and cytoprotective properties. This study was undertaken to test whether taurine coadministered with isotretinoin might be able to protect against the teratogenic effects of the retinoid. Our study failed to find any support for this speculation. Whether challenged against a 75 (mildly teratogenic) or 150 (very teratogenic) mg/kg/day dose of isotretinoin, taurine for the most part worsened the retinoid embryotoxicity. While in a few combinations taurine decreased the resorption or malformation rate associated with isotretinoin, the decrease was, at best, marginal. In no case was taurine able to decrease these rates to those noted in the controls. |
| doi_str_mv | 10.1016/0272-0590(90)90052-L |
| format | Article |
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Taurine, an amino sulfonic acid, has been shown to possess membrane-stabilizing and cytoprotective properties. This study was undertaken to test whether taurine coadministered with isotretinoin might be able to protect against the teratogenic effects of the retinoid. Our study failed to find any support for this speculation. Whether challenged against a 75 (mildly teratogenic) or 150 (very teratogenic) mg/kg/day dose of isotretinoin, taurine for the most part worsened the retinoid embryotoxicity. While in a few combinations taurine decreased the resorption or malformation rate associated with isotretinoin, the decrease was, at best, marginal. In no case was taurine able to decrease these rates to those noted in the controls.</description><identifier>ISSN: 0272-0590</identifier><identifier>EISSN: 1095-6832</identifier><identifier>DOI: 10.1016/0272-0590(90)90052-L</identifier><identifier>PMID: 2227153</identifier><identifier>CODEN: FAATDF</identifier><language>eng</language><publisher>Boston, MA: Elsevier Science (USA)</publisher><subject>Animals ; Biological and medical sciences ; Body Weight ; Drug toxicity and drugs side effects treatment ; Embryo, Mammalian - drug effects ; Female ; Gestational Age ; Isotretinoin - antagonists & inhibitors ; Isotretinoin - toxicity ; Medical sciences ; Miscellaneous (drug allergy, mutagens, teratogens...) ; Pharmacology. 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Taurine, an amino sulfonic acid, has been shown to possess membrane-stabilizing and cytoprotective properties. This study was undertaken to test whether taurine coadministered with isotretinoin might be able to protect against the teratogenic effects of the retinoid. Our study failed to find any support for this speculation. Whether challenged against a 75 (mildly teratogenic) or 150 (very teratogenic) mg/kg/day dose of isotretinoin, taurine for the most part worsened the retinoid embryotoxicity. While in a few combinations taurine decreased the resorption or malformation rate associated with isotretinoin, the decrease was, at best, marginal. In no case was taurine able to decrease these rates to those noted in the controls.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Body Weight</subject><subject>Drug toxicity and drugs side effects treatment</subject><subject>Embryo, Mammalian - drug effects</subject><subject>Female</subject><subject>Gestational Age</subject><subject>Isotretinoin - antagonists & inhibitors</subject><subject>Isotretinoin - toxicity</subject><subject>Medical sciences</subject><subject>Miscellaneous (drug allergy, mutagens, teratogens...)</subject><subject>Pharmacology. 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Drug treatments</topic><topic>Pregnancy</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Taurine - pharmacology</topic><topic>Teratogens</topic><toplevel>online_resources</toplevel><creatorcontrib>Agnish, Narsingh D.</creatorcontrib><creatorcontrib>Rusin, Gregory</creatorcontrib><creatorcontrib>DiNardo, Barbara</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Fundamental and applied toxicology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Agnish, Narsingh D.</au><au>Rusin, Gregory</au><au>DiNardo, Barbara</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Taurine failed to protect against the embryotoxic effects of isotretinoin in the rat</atitle><jtitle>Fundamental and applied toxicology</jtitle><addtitle>Fundam Appl Toxicol</addtitle><date>1990-08-01</date><risdate>1990</risdate><volume>15</volume><issue>2</issue><spage>249</spage><epage>257</epage><pages>249-257</pages><issn>0272-0590</issn><eissn>1095-6832</eissn><coden>FAATDF</coden><abstract>Experimental evidence exists to indicate that retinoids may act as detergents to disrupt biological membranes. Taurine, an amino sulfonic acid, has been shown to possess membrane-stabilizing and cytoprotective properties. This study was undertaken to test whether taurine coadministered with isotretinoin might be able to protect against the teratogenic effects of the retinoid. Our study failed to find any support for this speculation. Whether challenged against a 75 (mildly teratogenic) or 150 (very teratogenic) mg/kg/day dose of isotretinoin, taurine for the most part worsened the retinoid embryotoxicity. While in a few combinations taurine decreased the resorption or malformation rate associated with isotretinoin, the decrease was, at best, marginal. In no case was taurine able to decrease these rates to those noted in the controls.</abstract><cop>Boston, MA</cop><cop>San Diego, CA</cop><cop>New York, NY</cop><pub>Elsevier Science (USA)</pub><pmid>2227153</pmid><doi>10.1016/0272-0590(90)90052-L</doi><tpages>9</tpages></addata></record> |
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| source | MEDLINE; Alma/SFX Local Collection; Oxford University Press Journals Digital Archive Legacy |
| subjects | Animals Biological and medical sciences Body Weight Drug toxicity and drugs side effects treatment Embryo, Mammalian - drug effects Female Gestational Age Isotretinoin - antagonists & inhibitors Isotretinoin - toxicity Medical sciences Miscellaneous (drug allergy, mutagens, teratogens...) Pharmacology. Drug treatments Pregnancy Rats Rats, Inbred Strains Taurine - pharmacology Teratogens |
| title | Taurine failed to protect against the embryotoxic effects of isotretinoin in the rat |
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