Large-scale production of chiral alcohols with bakers' yeast
Chiral alcohols were produced on a large scale by developing effective regeneration systems of nicotinamide coenzymes in bakers' yeast cells. In the asymmetric reduction of prochiral ketones, ethanol is used instead of carbohydrate as the energy source for NAD(P)H regeneration. We propose an ov...
Gespeichert in:
| Veröffentlicht in: | Journal of Molecular Catalysis. B, Enzymatic Enzymatic, 1996-01, Vol.1 (2), p.45-52 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 52 |
|---|---|
| container_issue | 2 |
| container_start_page | 45 |
| container_title | Journal of Molecular Catalysis. B, Enzymatic |
| container_volume | 1 |
| creator | Kometani, Tadashi Yoshii, Hidefumi Matsuno, Ryuichi |
| description | Chiral alcohols were produced on a large scale by developing effective regeneration systems of nicotinamide coenzymes in bakers' yeast cells. In the asymmetric reduction of prochiral ketones, ethanol is used instead of carbohydrate as the energy source for NAD(P)H regeneration. We propose an overall scheme for NAD(P)H regeneration from NAD(P)
+ through the oxidative pathway of ethanol. In the oxidative resolution of a racemic alcohol, NAD
+ is effectively regenerated from NADH through the respiratory chain in the yeast cells. Thus, racemic 1,2-alkanediols were microbially resolved on a large scale by repeating the oxidative resolution and the asymmetric reduction. |
| doi_str_mv | 10.1016/1381-1177(95)00014-3 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_15714967</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>1381117795000143</els_id><sourcerecordid>15714967</sourcerecordid><originalsourceid>FETCH-LOGICAL-c400t-b017fcf1767a0c565c0ea41b269ca69f17512fc481aea428efd8bbe9c28a55eb3</originalsourceid><addsrcrecordid>eNp9kE1LxDAQhosouK7-Aw89iB-HaqZt2gREkMUvWPCi55BOJ260u9Gkq-y_N3VXj54SMs87M3mS5BDYOTCoLqAQkAHU9ankZ4wxKLNiKxmBqIusAC624_0X2U32QniNUA4gRsnlVPsXygLqjtJ379ol9tYtUmdSnFmvu1R36GauC-mX7Wdpo9_Ih5N0RTr0-8mO0V2gg805Tp5vb54m99n08e5hcj3NsGSszxoGtUEDdVVrhrziyEiX0OSVRF3JWOCQGywF6PieCzKtaBqSmAvNOTXFODle940Lfiwp9GpuA1LX6QW5ZVDAayhlVUewXIPoXQiejHr3dq79SgFTgyo1eFCDByW5-lGlihg72vTXgwjj9QJt-MsWTBZS8IhdrTGKf_205FVASwuk1nrCXrXO_j_nG41hfF4</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>15714967</pqid></control><display><type>article</type><title>Large-scale production of chiral alcohols with bakers' yeast</title><source>ScienceDirect Journals (5 years ago - present)</source><creator>Kometani, Tadashi ; Yoshii, Hidefumi ; Matsuno, Ryuichi</creator><creatorcontrib>Kometani, Tadashi ; Yoshii, Hidefumi ; Matsuno, Ryuichi</creatorcontrib><description>Chiral alcohols were produced on a large scale by developing effective regeneration systems of nicotinamide coenzymes in bakers' yeast cells. In the asymmetric reduction of prochiral ketones, ethanol is used instead of carbohydrate as the energy source for NAD(P)H regeneration. We propose an overall scheme for NAD(P)H regeneration from NAD(P)
+ through the oxidative pathway of ethanol. In the oxidative resolution of a racemic alcohol, NAD
+ is effectively regenerated from NADH through the respiratory chain in the yeast cells. Thus, racemic 1,2-alkanediols were microbially resolved on a large scale by repeating the oxidative resolution and the asymmetric reduction.</description><identifier>ISSN: 1381-1177</identifier><identifier>EISSN: 1873-3158</identifier><identifier>DOI: 10.1016/1381-1177(95)00014-3</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Asymmetric reduction ; Bakers' yeast ; Bioconversions. Hemisynthesis ; Biological and medical sciences ; Biotechnology ; Chiral alcohol ; Coenzyme regeneration ; Fundamental and applied biological sciences. Psychology ; Methods. Procedures. Technologies ; Oxidative resolution</subject><ispartof>Journal of Molecular Catalysis. B, Enzymatic, 1996-01, Vol.1 (2), p.45-52</ispartof><rights>1996</rights><rights>1996 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c400t-b017fcf1767a0c565c0ea41b269ca69f17512fc481aea428efd8bbe9c28a55eb3</citedby><cites>FETCH-LOGICAL-c400t-b017fcf1767a0c565c0ea41b269ca69f17512fc481aea428efd8bbe9c28a55eb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/1381-1177(95)00014-3$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>313,314,780,784,792,3548,27920,27922,27923,45993</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3093985$$DView record in Pascal Francis$$Hfree_for_read</backlink></links><search><creatorcontrib>Kometani, Tadashi</creatorcontrib><creatorcontrib>Yoshii, Hidefumi</creatorcontrib><creatorcontrib>Matsuno, Ryuichi</creatorcontrib><title>Large-scale production of chiral alcohols with bakers' yeast</title><title>Journal of Molecular Catalysis. B, Enzymatic</title><description>Chiral alcohols were produced on a large scale by developing effective regeneration systems of nicotinamide coenzymes in bakers' yeast cells. In the asymmetric reduction of prochiral ketones, ethanol is used instead of carbohydrate as the energy source for NAD(P)H regeneration. We propose an overall scheme for NAD(P)H regeneration from NAD(P)
+ through the oxidative pathway of ethanol. In the oxidative resolution of a racemic alcohol, NAD
+ is effectively regenerated from NADH through the respiratory chain in the yeast cells. Thus, racemic 1,2-alkanediols were microbially resolved on a large scale by repeating the oxidative resolution and the asymmetric reduction.</description><subject>Asymmetric reduction</subject><subject>Bakers' yeast</subject><subject>Bioconversions. Hemisynthesis</subject><subject>Biological and medical sciences</subject><subject>Biotechnology</subject><subject>Chiral alcohol</subject><subject>Coenzyme regeneration</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Methods. Procedures. Technologies</subject><subject>Oxidative resolution</subject><issn>1381-1177</issn><issn>1873-3158</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><recordid>eNp9kE1LxDAQhosouK7-Aw89iB-HaqZt2gREkMUvWPCi55BOJ260u9Gkq-y_N3VXj54SMs87M3mS5BDYOTCoLqAQkAHU9ankZ4wxKLNiKxmBqIusAC624_0X2U32QniNUA4gRsnlVPsXygLqjtJ379ol9tYtUmdSnFmvu1R36GauC-mX7Wdpo9_Ih5N0RTr0-8mO0V2gg805Tp5vb54m99n08e5hcj3NsGSszxoGtUEDdVVrhrziyEiX0OSVRF3JWOCQGywF6PieCzKtaBqSmAvNOTXFODle940Lfiwp9GpuA1LX6QW5ZVDAayhlVUewXIPoXQiejHr3dq79SgFTgyo1eFCDByW5-lGlihg72vTXgwjj9QJt-MsWTBZS8IhdrTGKf_205FVASwuk1nrCXrXO_j_nG41hfF4</recordid><startdate>19960101</startdate><enddate>19960101</enddate><creator>Kometani, Tadashi</creator><creator>Yoshii, Hidefumi</creator><creator>Matsuno, Ryuichi</creator><general>Elsevier B.V</general><general>Elsevier Science</general><scope>IQODW</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope></search><sort><creationdate>19960101</creationdate><title>Large-scale production of chiral alcohols with bakers' yeast</title><author>Kometani, Tadashi ; Yoshii, Hidefumi ; Matsuno, Ryuichi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c400t-b017fcf1767a0c565c0ea41b269ca69f17512fc481aea428efd8bbe9c28a55eb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Asymmetric reduction</topic><topic>Bakers' yeast</topic><topic>Bioconversions. Hemisynthesis</topic><topic>Biological and medical sciences</topic><topic>Biotechnology</topic><topic>Chiral alcohol</topic><topic>Coenzyme regeneration</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Methods. Procedures. Technologies</topic><topic>Oxidative resolution</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kometani, Tadashi</creatorcontrib><creatorcontrib>Yoshii, Hidefumi</creatorcontrib><creatorcontrib>Matsuno, Ryuichi</creatorcontrib><collection>Pascal-Francis</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Journal of Molecular Catalysis. B, Enzymatic</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kometani, Tadashi</au><au>Yoshii, Hidefumi</au><au>Matsuno, Ryuichi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Large-scale production of chiral alcohols with bakers' yeast</atitle><jtitle>Journal of Molecular Catalysis. B, Enzymatic</jtitle><date>1996-01-01</date><risdate>1996</risdate><volume>1</volume><issue>2</issue><spage>45</spage><epage>52</epage><pages>45-52</pages><issn>1381-1177</issn><eissn>1873-3158</eissn><abstract>Chiral alcohols were produced on a large scale by developing effective regeneration systems of nicotinamide coenzymes in bakers' yeast cells. In the asymmetric reduction of prochiral ketones, ethanol is used instead of carbohydrate as the energy source for NAD(P)H regeneration. We propose an overall scheme for NAD(P)H regeneration from NAD(P)
+ through the oxidative pathway of ethanol. In the oxidative resolution of a racemic alcohol, NAD
+ is effectively regenerated from NADH through the respiratory chain in the yeast cells. Thus, racemic 1,2-alkanediols were microbially resolved on a large scale by repeating the oxidative resolution and the asymmetric reduction.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><doi>10.1016/1381-1177(95)00014-3</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1381-1177 |
| ispartof | Journal of Molecular Catalysis. B, Enzymatic, 1996-01, Vol.1 (2), p.45-52 |
| issn | 1381-1177 1873-3158 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_15714967 |
| source | ScienceDirect Journals (5 years ago - present) |
| subjects | Asymmetric reduction Bakers' yeast Bioconversions. Hemisynthesis Biological and medical sciences Biotechnology Chiral alcohol Coenzyme regeneration Fundamental and applied biological sciences. Psychology Methods. Procedures. Technologies Oxidative resolution |
| title | Large-scale production of chiral alcohols with bakers' yeast |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-10T04%3A17%3A44IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Large-scale%20production%20of%20chiral%20alcohols%20with%20bakers'%20yeast&rft.jtitle=Journal%20of%20Molecular%20Catalysis.%20B,%20Enzymatic&rft.au=Kometani,%20Tadashi&rft.date=1996-01-01&rft.volume=1&rft.issue=2&rft.spage=45&rft.epage=52&rft.pages=45-52&rft.issn=1381-1177&rft.eissn=1873-3158&rft_id=info:doi/10.1016/1381-1177(95)00014-3&rft_dat=%3Cproquest_cross%3E15714967%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=15714967&rft_id=info:pmid/&rft_els_id=1381117795000143&rfr_iscdi=true |