Structure and Mechanism of Inosine Monophosphate Dehydrogenase in Complex with the Immunosuppressant Mycophenolic Acid

The structure of inosine-5′-monophosphate dehydrogenase (IMPDH) in complex with IMP and mycophenolic acid (MPA) has been determined by X-ray diffraction. IMPDH plays a central role in B and T lymphocyte replication. MPA is a potent IMPDH inhibitor and the active metabolite of an immunosuppressive dr...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Cell 1996-06, Vol.85 (6), p.921-930
Hauptverfasser:	Sintchak, Michael D., Fleming, Mark A., Futer, Olga, Raybuck, Scott A., Chambers, Stephen P., Caron, Paul R., Murcko, Mark A., Wilson, Keith P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Binding Sites Cricetinae Cricetulus Crystallography, X-Ray Humans Immunosuppressive Agents - metabolism IMP Dehydrogenase - antagonists & inhibitors IMP Dehydrogenase - chemistry IMP Dehydrogenase - genetics IMP Dehydrogenase - metabolism Inosine Monophosphate - metabolism Models, Molecular Molecular Sequence Data Mutation Mycophenolic Acid - analogs & derivatives Mycophenolic Acid - metabolism Potassium - metabolism Protein Binding Protein Conformation Structure-Activity Relationship
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!