Ricin Depresses Cardiac Function in the Rabbit Heart

Ricin, a toxic glycoprotein from the castor bean, causes myocardial hemorrhage and a decrease in blood pressure. We studied the effects of ricin on myocardial function in the isolated rabbit heart. Rabbits were given 0.22 μg/kg of ricin iv and 48 hr later, the heart was isolated and retrogradely per...

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Veröffentlicht in:	Toxicology and applied pharmacology 1996-05, Vol.138 (1), p.72-76
Hauptverfasser:	Ma, Lianmin, Hsu, Chia-Hsuh, Patterson, Eugene, Thadani, Udho, Robinson, Casey P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenergic beta-Agonists - pharmacology Adrenergic beta-Antagonists - pharmacology Animals Biological and medical sciences COEUR CONEJO (ORYCTOLAGUS) CONSOMMATION D'OXYGENE CONSUMO DE OXIGENO CORAZON Dihydroalprenolol - metabolism Electrocardiography Heart - drug effects Heart - physiology In Vitro Techniques Isoproterenol - pharmacology LAPIN (ORYCTOLAGUS) LECTINAS LECTINE Medical sciences Myocardial Contraction - drug effects Myocardium - metabolism Oxygen Consumption - drug effects Plant poisons toxicology PRESION SANGUINEA PRESSION SANGUINE Propranolol - pharmacology Rabbits RECEPTEUR D'HORMONE RECEPTORES DE HORMONAS Receptors, Adrenergic, beta - drug effects Receptors, Adrenergic, beta - metabolism Ricin - toxicity Ricinus communis TOXICIDAD TOXICITE Toxicology Ventricular Function, Left - drug effects
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