The regulation of tissue factor mRNA in human endothelial cells in response to endotoxin or phorbol ester

Tissue factor (TF) is the membrane-bound glycoprotein whose cofactor activity with factor VIIa causes activation of the extrinsic pathway of coagulation. The transition of endothelium to a procoagulant state by agents such as bacterial lipopolysaccharide (LPS) is the result of TF expression by these...

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Veröffentlicht in:	The Journal of biological chemistry 1990-06, Vol.265 (17), p.9782-9787
Hauptverfasser:	CROSSMAN, D. C, CARR, D. P, TUDDENHAM, E. G. D, PEARSON, J. D, MCVEY, J. H
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Cell Nucleus - metabolism Cell physiology Cells, Cultured Endothelium, Vascular - drug effects Endothelium, Vascular - metabolism Endotoxins - pharmacology Fundamental and applied biological sciences. Psychology Gene Expression Regulation Genes - drug effects Humans Kinetics Lipopolysaccharides - pharmacology Molecular and cellular biology Nucleic Acid Hybridization Responses to growth factors, tumor promotors, other factors RNA - genetics RNA - isolation & purification RNA Probes RNA, Messenger - drug effects RNA, Messenger - genetics RNA, Messenger - metabolism Tetradecanoylphorbol Acetate - pharmacology Thromboplastin - biosynthesis Thromboplastin - genetics
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