Selectivity in the Inhibition of HIV and FIV Protease: Inhibitory and Mechanistic Studies of Pyrrolidine-Containing .alpha.-Keto Amide and Hydroxyethylamine Core Structures

This paper describes the development of new pyrrolidine-containing alpha -keto amide and hydroxyethylamine core structures as mechanism based inhibitors of the HIV and FIV proteases. It was found that the alpha -keto amide core structure 2 is approximately 300-fold better than the corresponding hydr...

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Veröffentlicht in:	Journal of the American Chemical Society 1995-12, Vol.117 (48), p.11867-11878
Hauptverfasser:	Slee, Deborah H, Laslo, Karen L, Elder, John H, Ollmann, Ian R, Gustchina, Alla, Kervinen, Jukka, Zdanov, Alexander, Wlodawer, Alexander, Wong, Chi-Huey
Format:	Artikel
Sprache:	eng
Schlagworte:	feline immunodeficiency virus human immunodeficiency virus
Online-Zugang:	Volltext
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