Interaction with the Aromatic Hydrocarbon Receptor, CYP1A Induction, and Mutagenicity of a Series of Diaminotoluenes: Implications for Their Carcinogenicity

The present study was undertaken to provide a rationale for the marked difference in carcinogenic potential among isomeric diaminotoluenes, in relation to their ability to induce their own bioactivation through CYP1A induction, their genotoxic potential, and their ability to bind to the cytosolic ar...

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Veröffentlicht in:	Toxicology and applied pharmacology 1996-07, Vol.139 (1), p.203-211
Hauptverfasser:	Cheung, Yen-Ling, Snelling, Jacqueline, Mohammed, N.N.D., Gray, Tim J.B., Ioannides, Costas
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aroclors - metabolism Aroclors - toxicity Binding Sites Biological and medical sciences Carcinogenesis, carcinogens and anticarcinogens Carcinogens - metabolism Carcinogens - toxicity Chemical agents Chlorodiphenyl (54% Chlorine) Cytochrome P-450 CYP1A2 Cytochrome P-450 Enzyme System - biosynthesis Cytochrome P-450 Enzyme System - metabolism Electrophoresis, Polyacrylamide Gel Enzyme Induction - drug effects Male Medical sciences Mutagens - metabolism Mutagens - toxicity Mutation - drug effects Mutation - genetics Oxidoreductases - biosynthesis Oxidoreductases - metabolism Phenylenediamines - metabolism Phenylenediamines - toxicity Rats Rats, Wistar Receptors, Aryl Hydrocarbon - drug effects Receptors, Aryl Hydrocarbon - metabolism Stereoisomerism Tumors
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