Analytical Findings in a Suicide Involving Sodium Azide
A 47-year-old laboratory assistant ingested approximately 9 g of sodium azide powder and died 4 h later at a hospital. A high-performance liquid chromatographic method using diode-array detection has been developed for the determination of an azide benzoyl derivative in blood (after a simple deprote...
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| Veröffentlicht in: | Journal of analytical toxicology 1996-03, Vol.20 (2), p.134-138 |
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| container_end_page | 138 |
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| container_issue | 2 |
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| container_title | Journal of analytical toxicology |
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| creator | Marquet, Pierre Clément, Sophie Lotfi, Hayat Dreyfuss, Marie-France Debord, Jean Dumont, Daniel Lachâtre, Gérard |
| description | A 47-year-old laboratory assistant ingested approximately 9 g of sodium azide powder and died 4 h later at a hospital. A high-performance liquid chromatographic method using diode-array detection has been developed for the determination of an azide benzoyl derivative in blood (after a simple deproteinization) and in several tissues (after homogenization in a neutral buffer and deproteinization of the supernatant). The blood concentration in this case was lower than those previously published. The highest azide concentration was found in lung tissue. A complete toxicological screening revealed the presence of cyanide in blood, which has been previously reported twice, but for the first time, it was confirmed by mass spectrometry. Whether the production of cyanide in the presence of azide took place in vivo or postmortem remains unknown; the nature of the metabolic pathway involved also remains unknown. |
| doi_str_mv | 10.1093/jat/20.2.134 |
| format | Article |
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A high-performance liquid chromatographic method using diode-array detection has been developed for the determination of an azide benzoyl derivative in blood (after a simple deproteinization) and in several tissues (after homogenization in a neutral buffer and deproteinization of the supernatant). The blood concentration in this case was lower than those previously published. The highest azide concentration was found in lung tissue. A complete toxicological screening revealed the presence of cyanide in blood, which has been previously reported twice, but for the first time, it was confirmed by mass spectrometry. Whether the production of cyanide in the presence of azide took place in vivo or postmortem remains unknown; the nature of the metabolic pathway involved also remains unknown.</description><identifier>ISSN: 0146-4760</identifier><identifier>EISSN: 1945-2403</identifier><identifier>DOI: 10.1093/jat/20.2.134</identifier><identifier>PMID: 8868407</identifier><identifier>CODEN: JATOD3</identifier><language>eng</language><publisher>Niles, IL: Oxford University Press</publisher><subject>Azides - blood ; Azides - poisoning ; Biological and medical sciences ; Blood ; Blood levels ; Chemical and industrial products toxicology. Toxic occupational diseases ; Chromatography, High Pressure Liquid ; Cyanide ; Deproteinization ; Fatal Outcome ; Hospitals ; Humans ; Indicators and Reagents ; Lung ; Male ; Mass spectroscopy ; Medical sciences ; Metabolic pathways ; Metals and various inorganic compounds ; Middle Aged ; Powder ; Sodium Azide ; Spectrophotometry, Ultraviolet ; Suicide ; Toxicology</subject><ispartof>Journal of analytical toxicology, 1996-03, Vol.20 (2), p.134-138</ispartof><rights>1996</rights><rights>1996 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c477t-3f79a428d2e75e8f6783e3d5310f5a3ddae9534ad7b968bf88601121108ac8e3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1583,27923,27924</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3018162$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8868407$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Marquet, Pierre</creatorcontrib><creatorcontrib>Clément, Sophie</creatorcontrib><creatorcontrib>Lotfi, Hayat</creatorcontrib><creatorcontrib>Dreyfuss, Marie-France</creatorcontrib><creatorcontrib>Debord, Jean</creatorcontrib><creatorcontrib>Dumont, Daniel</creatorcontrib><creatorcontrib>Lachâtre, Gérard</creatorcontrib><title>Analytical Findings in a Suicide Involving Sodium Azide</title><title>Journal of analytical toxicology</title><addtitle>Journal of Analytical Toxicology</addtitle><addtitle>J Anal Toxicol</addtitle><description>A 47-year-old laboratory assistant ingested approximately 9 g of sodium azide powder and died 4 h later at a hospital. A high-performance liquid chromatographic method using diode-array detection has been developed for the determination of an azide benzoyl derivative in blood (after a simple deproteinization) and in several tissues (after homogenization in a neutral buffer and deproteinization of the supernatant). The blood concentration in this case was lower than those previously published. The highest azide concentration was found in lung tissue. A complete toxicological screening revealed the presence of cyanide in blood, which has been previously reported twice, but for the first time, it was confirmed by mass spectrometry. Whether the production of cyanide in the presence of azide took place in vivo or postmortem remains unknown; the nature of the metabolic pathway involved also remains unknown.</description><subject>Azides - blood</subject><subject>Azides - poisoning</subject><subject>Biological and medical sciences</subject><subject>Blood</subject><subject>Blood levels</subject><subject>Chemical and industrial products toxicology. Toxic occupational diseases</subject><subject>Chromatography, High Pressure Liquid</subject><subject>Cyanide</subject><subject>Deproteinization</subject><subject>Fatal Outcome</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Indicators and Reagents</subject><subject>Lung</subject><subject>Male</subject><subject>Mass spectroscopy</subject><subject>Medical sciences</subject><subject>Metabolic pathways</subject><subject>Metals and various inorganic compounds</subject><subject>Middle Aged</subject><subject>Powder</subject><subject>Sodium Azide</subject><subject>Spectrophotometry, Ultraviolet</subject><subject>Suicide</subject><subject>Toxicology</subject><issn>0146-4760</issn><issn>1945-2403</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp90EFLwzAUB_AgypzTm1ehB1EPdstL0iQ9juF0MPCw3UvWpJLRprNpB_PTL7iy404P3vvx3uOP0CPgMeCUTraqnRA8JmOg7AoNIWVJTBim12iIgfGYCY5v0Z33W4yBS04HaCAllwyLIRJTp8pDa3NVRnPrtHU_PrIuUtGqs7nVJlq4fV3uQz9a1dp2VTT9C-17dFOo0puHvo7Qev6xnn3Fy-_PxWy6jHMmRBvTQqSKEamJEYmRBReSGqoTCrhIFNVamTShTGmxSbncFOEvDEAAsFS5NHSEXk5rd0392xnfZpX1uSlL5Uzd-QwSLolkEODbZRiSYpxzoIG-n2je1N43psh2ja1Ucwjo32Uh0YzgjGQh0cCf-s3dpjL6jPsIw_y5nysfUiwa5XLrz4xikMBJYK8nVne7yweP7xiIhA</recordid><startdate>19960301</startdate><enddate>19960301</enddate><creator>Marquet, Pierre</creator><creator>Clément, Sophie</creator><creator>Lotfi, Hayat</creator><creator>Dreyfuss, Marie-France</creator><creator>Debord, Jean</creator><creator>Dumont, Daniel</creator><creator>Lachâtre, Gérard</creator><general>Oxford University Press</general><general>Preston</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>19960301</creationdate><title>Analytical Findings in a Suicide Involving Sodium Azide</title><author>Marquet, Pierre ; Clément, Sophie ; Lotfi, Hayat ; Dreyfuss, Marie-France ; Debord, Jean ; Dumont, Daniel ; Lachâtre, Gérard</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c477t-3f79a428d2e75e8f6783e3d5310f5a3ddae9534ad7b968bf88601121108ac8e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Azides - blood</topic><topic>Azides - poisoning</topic><topic>Biological and medical sciences</topic><topic>Blood</topic><topic>Blood levels</topic><topic>Chemical and industrial products toxicology. Toxic occupational diseases</topic><topic>Chromatography, High Pressure Liquid</topic><topic>Cyanide</topic><topic>Deproteinization</topic><topic>Fatal Outcome</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Indicators and Reagents</topic><topic>Lung</topic><topic>Male</topic><topic>Mass spectroscopy</topic><topic>Medical sciences</topic><topic>Metabolic pathways</topic><topic>Metals and various inorganic compounds</topic><topic>Middle Aged</topic><topic>Powder</topic><topic>Sodium Azide</topic><topic>Spectrophotometry, Ultraviolet</topic><topic>Suicide</topic><topic>Toxicology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Marquet, Pierre</creatorcontrib><creatorcontrib>Clément, Sophie</creatorcontrib><creatorcontrib>Lotfi, Hayat</creatorcontrib><creatorcontrib>Dreyfuss, Marie-France</creatorcontrib><creatorcontrib>Debord, Jean</creatorcontrib><creatorcontrib>Dumont, Daniel</creatorcontrib><creatorcontrib>Lachâtre, Gérard</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Journal of analytical toxicology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Marquet, Pierre</au><au>Clément, Sophie</au><au>Lotfi, Hayat</au><au>Dreyfuss, Marie-France</au><au>Debord, Jean</au><au>Dumont, Daniel</au><au>Lachâtre, Gérard</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Analytical Findings in a Suicide Involving Sodium Azide</atitle><jtitle>Journal of analytical toxicology</jtitle><stitle>Journal of Analytical Toxicology</stitle><addtitle>J Anal Toxicol</addtitle><date>1996-03-01</date><risdate>1996</risdate><volume>20</volume><issue>2</issue><spage>134</spage><epage>138</epage><pages>134-138</pages><issn>0146-4760</issn><eissn>1945-2403</eissn><coden>JATOD3</coden><abstract>A 47-year-old laboratory assistant ingested approximately 9 g of sodium azide powder and died 4 h later at a hospital. A high-performance liquid chromatographic method using diode-array detection has been developed for the determination of an azide benzoyl derivative in blood (after a simple deproteinization) and in several tissues (after homogenization in a neutral buffer and deproteinization of the supernatant). The blood concentration in this case was lower than those previously published. The highest azide concentration was found in lung tissue. A complete toxicological screening revealed the presence of cyanide in blood, which has been previously reported twice, but for the first time, it was confirmed by mass spectrometry. Whether the production of cyanide in the presence of azide took place in vivo or postmortem remains unknown; the nature of the metabolic pathway involved also remains unknown.</abstract><cop>Niles, IL</cop><pub>Oxford University Press</pub><pmid>8868407</pmid><doi>10.1093/jat/20.2.134</doi><tpages>5</tpages></addata></record> |
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| ispartof | Journal of analytical toxicology, 1996-03, Vol.20 (2), p.134-138 |
| issn | 0146-4760 1945-2403 |
| language | eng |
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| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current); EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Azides - blood Azides - poisoning Biological and medical sciences Blood Blood levels Chemical and industrial products toxicology. Toxic occupational diseases Chromatography, High Pressure Liquid Cyanide Deproteinization Fatal Outcome Hospitals Humans Indicators and Reagents Lung Male Mass spectroscopy Medical sciences Metabolic pathways Metals and various inorganic compounds Middle Aged Powder Sodium Azide Spectrophotometry, Ultraviolet Suicide Toxicology |
| title | Analytical Findings in a Suicide Involving Sodium Azide |
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