DNA-dependent Protein Kinase Is a Target for a CPP32-like Apoptotic Protease

We demonstrate that the catalytic subunit of the DNA-dependent protein kinase (DNA-PK cs ) is specifically, proteolytically cleaved in HL-60 cells treated with staurosporine (STS), a potent inducer of apoptosis. The proteolysis of DNA-PK cs correlated with or preceded apoptotic chromosomal DNA degra...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The Journal of biological chemistry 1996-10, Vol.271 (40), p.25035-25040
Hauptverfasser:	Han, Z, Malik, N, Carter, T, Reeves, W H, Wyche, J H, Hendrickson, E A
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkylating Agents - pharmacology Apoptosis Caspase 3 Caspases Cysteine Endopeptidases - metabolism DNA-Activated Protein Kinase DNA-Binding Proteins Enzyme Inhibitors - pharmacology Ethylmaleimide - pharmacology HL-60 Cells Hydrolysis Iodoacetates - pharmacology Iodoacetic Acid Protein-Serine-Threonine Kinases - antagonists & inhibitors Protein-Serine-Threonine Kinases - metabolism Proto-Oncogene Proteins c-bcl-2 - metabolism Substrate Specificity
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!